Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.3882 | 0.3759 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.3882 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.3882 | 0.3759 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.2526 | 0.2375 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.2526 | 0.632 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.2526 | 0.2375 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.1647 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 0.3882 | 0.3759 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.2526 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 0.3882 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.2526 | 0.2375 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.0198 | 0.0784 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.2526 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.2526 | 0.2375 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 0.3882 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0198 | 0.0784 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.0198 | 0.0784 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.026 uM | Inhibitory activity of the compound against human quiescent cell proline dipeptidase | ChEMBL. | 15012982 |
IC50 (binding) | = 0.026 uM | Inhibitory activity of the compound against human quiescent cell proline dipeptidase | ChEMBL. | 15012982 |
IC50 (binding) | = 0.043 uM | Inhibitory activity against human recombinant Dipeptidyl-peptidase IV | ChEMBL. | 15012982 |
IC50 (binding) | = 0.043 uM | Inhibitory activity against human recombinant Dipeptidyl-peptidase IV | ChEMBL. | 15012982 |
IC50 (binding) | = 2.1 uM | Inhibitory activity against human prolylendopeptidase | ChEMBL. | 15012982 |
IC50 (binding) | = 2.1 uM | Inhibitory activity against human prolylendopeptidase | ChEMBL. | 15012982 |
IC50 (binding) | > 100 uM | Inhibitory activity against human aminopeptidase P | ChEMBL. | 15012982 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.