Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Protein farnesyltransferase | Starlite/ChEMBL | References |
Homo sapiens | protein geranylgeranyltransferase type I, beta subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | protein farnesyltransferase beta subunit | protein geranylgeranyltransferase type I, beta subunit | 377 aa | 361 aa | 26.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0158 | 0.2689 | 0.4214 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0104 | 0.073 | 0.0006 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0111 | 0.1 | 0.1567 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0111 | 0.1 | 0.1567 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0104 | 0.073 | 0.001 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0111 | 0.1 | 0.1567 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.011 | 0.0963 | 0.0258 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0258 | 0.6381 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0104 | 0.0724 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0111 | 0.1 | 0.1567 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0104 | 0.073 | 0.001 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0158 | 0.2689 | 0.3473 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0357 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0111 | 0.1 | 0.1567 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0111 | 0.1 | 0.1567 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0111 | 0.1 | 0.1567 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0115 | 0.1136 | 0.178 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0258 | 0.6381 | 1 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0258 | 0.6381 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0357 | 1 | 1 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0258 | 0.6381 | 0.6099 |
Schistosoma mansoni | glutamate receptor kainate | 0.0104 | 0.073 | 0.001 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.0104 | 0.0724 | 0.1135 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.011 | 0.0963 | 0.0258 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0104 | 0.073 | 0.0006 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0158 | 0.2689 | 0.4214 |
Schistosoma mansoni | glutamate receptor kainate | 0.0104 | 0.073 | 0.001 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0258 | 0.6381 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0104 | 0.073 | 0.1143 |
Giardia lamblia | Prenyltransferase | 0.0104 | 0.0724 | 0.5 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0104 | 0.073 | 0.001 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.0104 | 0.0724 | 0.1135 |
Echinococcus granulosus | glutamate receptor 2 | 0.0111 | 0.1 | 0.1567 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0188 | 0.3799 | 0.5435 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0104 | 0.0724 | 0.5 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0258 | 0.6381 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0111 | 0.1 | 0.1567 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0104 | 0.073 | 0.0006 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0104 | 0.0724 | 0.5 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0104 | 0.073 | 0.001 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0357 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0258 | 0.6381 | 1 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.011 | 0.0963 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0104 | 0.073 | 0.0006 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0111 | 0.1 | 0.1567 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0115 | 0.1136 | 0.178 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.361 | 0.3112 |
Trypanosoma brucei | lanosterol synthase | 0.011 | 0.0963 | 0.0258 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0258 | 0.6381 | 0.6099 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 nM | Inhibition of Farnesyltransferase in v-Ha-ras-transformed Rat1 cells using Radiotracer Assay (CRAFT1); ND=Not determined | ChEMBL. | 11965368 |
IC50 (functional) | = 8 nM | Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM. | ChEMBL. | 11965368 |
IC50 (functional) | = 8 nM | Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM. | ChEMBL. | 11965368 |
IC50 (functional) | = 509 nM | Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-terminus of human K-Ras. | ChEMBL. | 11965368 |
IC50 (functional) | = 509 nM | Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-terminus of human K-Ras. | ChEMBL. | 11965368 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.