Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0038 | 0.0255 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0028 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Echinococcus granulosus | geminin | 0.0181 | 0.3784 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0028 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.6401 | 0.6401 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | POT family protein | 0.0043 | 0.0359 | 0.0359 |
Brugia malayi | POT family protein | 0.0043 | 0.0359 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.3784 | 0.6157 |
Leishmania major | glutaminyl cyclase, putative | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0038 | 0.0255 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0276 | 0.6146 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.3784 | 0.6157 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.905 | 0.905 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0028 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0181 | 0.3784 | 0.3883 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0422 | 0.9745 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 100 uM | Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain | ChEMBL. | 1849994 |
Ki (binding) | > 100 uM | Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain | ChEMBL. | 1849994 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.