Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | GMP reductase | 0.0087 | 0.4397 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0087 | 0.4397 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1028 | 0.0911 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0087 | 0.4397 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0036 | 0.1017 | 0.1775 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.3653 | 0.8191 |
Loa Loa (eye worm) | GMP reductase | 0.0036 | 0.1017 | 0.2313 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0087 | 0.4397 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 1 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0087 | 0.4397 | 0.4397 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0087 | 0.4397 | 0.4324 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0082 | 0.4053 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0087 | 0.4397 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0087 | 0.4397 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0087 | 0.4397 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1479 | 0.3365 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0087 | 0.4397 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1192 | 0.2711 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3366 | 0.7656 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0087 | 0.4397 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.2625 | 0.2529 |
Onchocerca volvulus | Putative GMP reductase | 0.0036 | 0.1017 | 0.5 |
Toxoplasma gondii | IMP dehydrogenas | 0.0087 | 0.4397 | 0.5 |
Brugia malayi | GMP reductase | 0.0036 | 0.1017 | 0.1775 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.2866 | 0.2866 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0046 | 0.165 | 0.0954 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0087 | 0.4397 | 0.4324 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1028 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1351 | 0.3073 |
Trypanosoma brucei | GMP reductase | 0.0087 | 0.4397 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.2625 | 0.2529 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1187 | 0.2189 |
Trypanosoma cruzi | GMP reductase | 0.0087 | 0.4397 | 0.5 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0082 | 0.4053 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0087 | 0.4397 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0128 | 0.0128 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0087 | 0.4397 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0087 | 0.4397 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0036 | 0.1017 | 0.1775 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0082 | 0.4053 | 0.8869 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0087 | 0.4397 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 7 ug kg-1 | In vivo beta adrenergic blocking potency was determined by inhibition of tachycardia produced by isoproterenol (0.2 mg/kg iv) in cat preparation | ChEMBL. | 6128420 |
Inhibition (functional) | = 18 % | In vivo beta adrenergic blocking potency was determined by inhibition of depressor response produced by isoproterenol (0.2 mg/kg iv) in cat preparation | ChEMBL. | 6128420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.