Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.3003 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.3003 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.3003 | 0.2375 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.3003 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.3003 | 0.2375 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.3003 | 0.2375 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 0.4273 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.4273 | 0.3759 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0824 | 0.0784 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.4273 | 0.3759 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.0824 | 0.0784 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0824 | 0.0784 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0.0638 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0824 | 0.0784 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 0.4273 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.3003 | 0.2375 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.218 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0.0638 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3003 | 0.7029 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0087 | 0.0824 | 0.1928 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.3003 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 0.4273 | 0.3759 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.0824 | 0.0784 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.4273 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.3003 | 0.7029 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.014 uM | Inhibitory activity of the compound against human quiescent cell proline dipeptidase | ChEMBL. | 15012982 |
IC50 (binding) | = 0.014 uM | Inhibitory activity of the compound against human quiescent cell proline dipeptidase | ChEMBL. | 15012982 |
IC50 (binding) | = 0.28 uM | Inhibitory activity against human recombinant Dipeptidyl-peptidase IV | ChEMBL. | 15012982 |
IC50 (binding) | = 0.28 uM | Inhibitory activity against human recombinant Dipeptidyl-peptidase IV | ChEMBL. | 15012982 |
IC50 (binding) | = 19 uM | Inhibitory activity against human prolylendopeptidase | ChEMBL. | 15012982 |
IC50 (binding) | = 19 uM | Inhibitory activity against human prolylendopeptidase | ChEMBL. | 15012982 |
IC50 (binding) | > 100 uM | Inhibitory activity against human aminopeptidase P | ChEMBL. | 15012982 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.