Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0256 | 0.1901 | 0.116 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0256 | 0.1901 | 0.116 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0256 | 0.1901 | 0.5 |
Leishmania major | trypanothione reductase | 0.074 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.074 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0256 | 0.1901 | 0.116 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.0838 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.074 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0256 | 0.1901 | 0.116 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0256 | 0.1901 | 0.1901 |
Plasmodium falciparum | thioredoxin reductase | 0.074 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.074 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.074 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0256 | 0.1901 | 0.1234 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0193 | 0.0838 | 0.4409 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0256 | 0.1901 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.074 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0256 | 0.1901 | 0.116 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.0838 | 0.0084 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.074 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0256 | 0.1901 | 1 |
Treponema pallidum | NADH oxidase | 0.0256 | 0.1901 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0256 | 0.1901 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0256 | 0.1901 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0256 | 0.1901 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0256 | 0.1901 | 0.5 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0256 | 0.1901 | 0.116 |
Plasmodium falciparum | thioredoxin reductase | 0.0256 | 0.1901 | 0.116 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.0838 | 0.4409 |
Plasmodium falciparum | glutathione reductase | 0.074 | 1 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0256 | 0.1901 | 0.116 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0256 | 0.1901 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.074 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0256 | 0.1901 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0256 | 0.1901 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0256 | 0.1901 | 0.116 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.074 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.074 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.074 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.074 | 1 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.0838 | 0.4409 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0256 | 0.1901 | 0.1901 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.069 uM | In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene | ChEMBL. | 9526562 |
IC50 (binding) | = 0.069 uM | In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene | ChEMBL. | 9526562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.