Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | inosine-uridine preferring nucleoside hydrolase, putative | 0.0128 | 0.1133 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.491 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.0936 | 0.067 |
Leishmania major | nonspecific nucleoside hydrolase | 0.0128 | 0.1133 | 0.0739 |
Trypanosoma brucei | inosine-adenosine-guanosine-nucleosidehydrolase | 0.0485 | 1 | 1 |
Trypanosoma cruzi | inosine-adenosine-guanosine-nucleosidehydrolase, putative | 0.0485 | 1 | 1 |
Trichomonas vaginalis | inosine-uridine preferring nucleoside hydrolase, putative | 0.0128 | 0.1133 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.014 | 0.1415 | 0.0748 |
Echinococcus multilocularis | integrin alpha 3 | 0.0142 | 0.1462 | 0.2977 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.0936 | 0.067 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.7348 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.5021 | 0.6614 |
Trypanosoma cruzi | inosine-guanine nucleoside hydrolase, putative | 0.0128 | 0.1133 | 0.0739 |
Schistosoma mansoni | integrin alpha | 0.0185 | 0.2534 | 0.728 |
Leishmania major | inosine-guanine nucleoside hydrolase, putative | 0.0128 | 0.1133 | 0.0739 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0235 | 0.3787 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.348 | 1 |
Trichomonas vaginalis | inosine-uridine preferring nucleoside hydrolase, putative | 0.0128 | 0.1133 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.491 | 1 |
Trichomonas vaginalis | inosine-uridine preferring nucleoside hydrolase, putative | 0.0128 | 0.1133 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1547 | 0.156 |
Trypanosoma cruzi | inosine-adenosine-guanosine-nucleosidehydrolase, putative | 0.0485 | 1 | 1 |
Echinococcus granulosus | integrin alpha 3 | 0.0142 | 0.1462 | 0.2977 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1415 | 0.1368 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.7348 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.2534 | 0.2492 |
Giardia lamblia | Hypothetical protein | 0.0128 | 0.1133 | 0.5 |
Entamoeba histolytica | Inosine-uridine preferring nucleoside hydrolase, putative | 0.0128 | 0.1133 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.16 uM | In vitro inhibitory activity against blockage of binding of fibrinogen to purified human GPIIbIIIa | ChEMBL. | 11392540 |
IC50 (binding) | = 0.16 uM | In vitro inhibitory activity against blockage of binding of fibrinogen to purified human GPIIbIIIa | ChEMBL. | 11392540 |
IC50 (functional) | = 0.89 uM | In vitro ability to inhibit the aggregation of ADP-stimulated human platelets | ChEMBL. | 11392540 |
IC50 (functional) | = 0.89 uM | In vitro ability to inhibit the aggregation of ADP-stimulated human platelets | ChEMBL. | 11392540 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11392540 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.