Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin I2 (prostacyclin) receptor (IP) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 2 (subtype EP2), 53kDa | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin F receptor (FP) | Starlite/ChEMBL | References |
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 3 (subtype EP3) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin D2 receptor (DP) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 1 (subtype EP1), 42kDa | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | rhodopsin orphan GPCR | prostaglandin D2 receptor (DP) | 359 aa | 312 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0279 | 1 | 0.5 | |
Onchocerca volvulus | 0.0279 | 1 | 0.5 | |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0279 | 1 | 1 |
Onchocerca volvulus | 0.0279 | 1 | 0.5 | |
Onchocerca volvulus | 0.0279 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.7493 | 1 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0279 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.2595 | 0.331 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1955 | 0.2436 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0279 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 90 nM | Affinity for human Prostanoid FP receptor expressed in COS-7 cells | ChEMBL. | 10715159 |
IC50 (binding) | = 90 nM | Affinity for human Prostanoid FP receptor expressed in COS-7 cells | ChEMBL. | 10715159 |
IC50 (binding) | = 5000 nM | Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. | ChEMBL. | 10715159 |
IC50 (binding) | = 5000 nM | Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostanoid EP2 receptor expressed in CHO cells | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostanoid EP3 receptor expressed in CHO cell line | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostanoid EP4 receptor expressed in CHO cells | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostanoid TP receptor expressed in CHO cells | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for human Prostaglandin D2 receptor expressed in HEK-293 cells | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostaglandin I2 receptor expressed in CHO cells | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostanoid EP2 receptor expressed in CHO cells | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostanoid EP3 receptor expressed in CHO cell line | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostanoid EP4 receptor expressed in CHO cells | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostanoid TP receptor expressed in CHO cells | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for human Prostaglandin D2 receptor expressed in HEK-293 cells | ChEMBL. | 10715159 |
IC50 (binding) | > 10000 nM | Affinity for Prostaglandin I2 receptor expressed in CHO cells | ChEMBL. | 10715159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.