Detailed information for compound 307306

Basic information

Technical information
  • TDR Targets ID: 307306
  • Name: 2-(2-methoxyphenyl)-N,N-dipropylcyclopropan-1 -amine
  • MW: 247.376 | Formula: C16H25NO
  • H donors: 0 H acceptors: 0 LogP: 3.97 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C1CC1c1ccccc1OC)CCC
  • InChi: 1S/C16H25NO/c1-4-10-17(11-5-2)15-12-14(15)13-8-6-7-9-16(13)18-3/h6-9,14-15H,4-5,10-12H2,1-3H3
  • InChiKey: NHIZHIQMHLZUQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-methoxyphenyl)-N,N-dipropyl-cyclopropanamine
  • 2-(2-methoxyphenyl)-N,N-dipropylcyclopropanamine
  • 2-(2-methoxyphenyl)-N,N-dipropyl-cyclopropan-1-amine
  • [2-(2-methoxyphenyl)cyclopropyl]-dipropyl-amine
  • 2-(2-methoxyphenyl)-N,N-dipropyl-1-cyclopropanamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0364 0.3185 0.9755
Schistosoma mansoni growth hormone secretagogue receptor 0.0044 0.0099 0.023
Brugia malayi Melatonin receptor type 1A 0.0044 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0099 0.0303
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0044 0.0099 0.023
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0135 0.0981 0.096
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi Dopamine receptor protein 2 0.0044 0.0099 0.0233
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0099 0.0076
Toxoplasma gondii hypothetical protein 0.0135 0.0981 0.1377
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus biogenic amine 5HT receptor 0.0191 0.1514 0.1494
Trypanosoma cruzi lanosterol synthase, putative 0.04 0.3526 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0099 0.023
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0099 0.0076
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0099 0.0076
Echinococcus granulosus g protein coupled receptor 0.0044 0.0099 0.0076
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0135 0.0981 0.3081
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.0099 0.0076
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0135 0.0981 0.3081
Echinococcus granulosus g protein coupled receptor 0.0044 0.0099 0.0076
Echinococcus granulosus allatostatin A receptor 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0373 0.3265 1
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.0981 0.1215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0099 0.023
Echinococcus multilocularis neuropeptide receptor A26 0.0044 0.0099 0.0076
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0045 0.0022
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0099 0.0076
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0135 0.0981 0.2956
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0044 0.0099 0.0076
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0135 0.0981 0.1377
Schistosoma mansoni hypothetical protein 0.0169 0.1304 0.3901
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0099 0.063 0.1976
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus tachykinin peptides receptor 99D 0.0044 0.0099 0.0076
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0135 0.0981 0.303
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0364 0.3185 1
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0364 0.3185 1
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0099 0.023
Schistosoma mansoni neuropeptide f receptor 76f 0.0044 0.0099 0.023
Brugia malayi GnHR receptor homolog 0.0044 0.0099 0.0233
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0099 0.023
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0044 0.0099 0.0233
Trypanosoma cruzi lanosterol synthase, putative 0.04 0.3526 1
Echinococcus granulosus neuropeptide receptor 0.0044 0.0099 0.0076
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0135 0.0981 0.1215
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0099 0.0076
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0135 0.0981 0.303
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0044 0.0099 0.0076
Loa Loa (eye worm) TYRA-2 protein 0.0044 0.0099 0.0303
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0099 0.063 0.1928
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0364 0.3185 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0135 0.0981 0.2956
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0044 0.0099 0.0233
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Echinococcus granulosus peptide allatostatin:somatostatin 0.0044 0.0099 0.0076
Leishmania major farnesyltransferase beta subunit 0.0364 0.3185 0.9751
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0044 0.0099 0.023
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0099 0.023
Schistosoma mansoni neuropeptide receptor 0.0044 0.0099 0.023
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0044 0.0099 0.0076
Brugia malayi Serotonin receptor 0.0044 0.0099 0.0233
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0044 0.0099 0.0076
Echinococcus granulosus sex peptide receptor 0.0044 0.0099 0.0076
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0364 0.3185 1
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0099 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0364 0.3185 0.3169
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0044 0.0099 0.023
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0099 0.0303
Schistosoma mansoni hypothetical protein 0.0044 0.0099 0.023
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0135 0.0981 0.096
Trypanosoma brucei C-8 sterol isomerase, putative 0.0373 0.3265 0.91
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0135 0.0981 0.1215
Echinococcus granulosus somatostatin receptor 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0364 0.3185 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus multilocularis sodium channel protein 0.0039 0.0052 0.0029
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0099 0.063 0.1917
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0099 0.0076
Schistosoma mansoni opsin-like receptor 0.0044 0.0099 0.023
Schistosoma mansoni hypothetical protein 0.0044 0.0099 0.023
Loa Loa (eye worm) hypothetical protein 0.0099 0.063 0.1928
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Schistosoma mansoni neuropeptide receptor 0.0044 0.0099 0.023
Echinococcus granulosus geminin 0.0169 0.1304 0.1284
Echinococcus multilocularis dro:myosuppressin receptor 0.0044 0.0099 0.0076
Leishmania major C-8 sterol isomerase-like protein 0.0373 0.3265 1
Schistosoma mansoni hypothetical protein 0.0044 0.0099 0.023
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0099 0.0076
Echinococcus multilocularis neuropeptide s receptor 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0364 0.3185 1
Onchocerca volvulus 0.0135 0.0981 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0044 0.0099 0.0076
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0135 0.0981 0.1215
Echinococcus multilocularis G protein coupled receptor 139 0.0044 0.0099 0.0076
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0044 0.0099 0.023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0099 0.023
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0099 0.063 0.187
Trypanosoma cruzi hypothetical protein, conserved 0.0135 0.0981 0.1215
Echinococcus multilocularis neuropeptide FF receptor 2 0.0044 0.0099 0.0076
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0099 0.0076
Giardia lamblia Prenyltransferase 0.0364 0.3185 1
Echinococcus multilocularis sex peptide receptor 0.0044 0.0099 0.0076
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0135 0.0981 0.096
Schistosoma mansoni adenoreceptor 0.0044 0.0099 0.023
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0077 0.0164
Schistosoma mansoni histamine h1 receptor 0.0044 0.0099 0.023
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0099 0.063 0.1976
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.02 0.0611
Echinococcus granulosus hypothetical protein 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0099 0.023
Trypanosoma brucei lanosterol synthase 0.04 0.3526 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0044 0.0099 0.0233
Brugia malayi RE15519p 0.0044 0.0099 0.0233
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0364 0.3185 1
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0099 0.0303
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0135 0.0981 0.3006
Giardia lamblia Rab geranylgeranyltransferase 0.0135 0.0981 0.1377
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0364 0.3185 0.8824
Loa Loa (eye worm) hypothetical protein 0.0135 0.0981 0.3006
Trypanosoma brucei hypothetical protein, conserved 0.0135 0.0981 0.1215
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0077 0.0164
Schistosoma mansoni alpha-1 adrenergic receptor 0.0044 0.0099 0.023
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0135 0.0981 0.2919
Schistosoma mansoni neuropeptide receptor 0.0044 0.0099 0.023
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0373 0.3265 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0099 0.023
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus sodium channel protein 0.0039 0.0052 0.0029
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0099 0.0076
Schistosoma mansoni myosin xvIII 0.0044 0.0099 0.023
Echinococcus multilocularis g-protein coupled receptor 0.0044 0.0099 0.0076
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Echinococcus granulosus g protein coupled receptor 0.0044 0.0099 0.0076
Brugia malayi Dopamine receptor protein 1 0.0044 0.0099 0.0233
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Schistosoma mansoni opsin-like receptor 0.0044 0.0099 0.023
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0045 0.0022
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0099 0.0076
Schistosoma mansoni amine GPCR 0.0044 0.0099 0.023
Echinococcus multilocularis orexin receptor type 2 0.0044 0.0099 0.0076
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0044 0.0099 0.0233
Giardia lamblia Rab geranylgeranyltransferase 0.0135 0.0981 0.1377
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0099 0.0076
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0099 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0099 0.023
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0099 0.063 0.1846
Echinococcus multilocularis serotonin receptor 0.0191 0.1514 0.1494
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0099 0.0076
Brugia malayi follicle stimulating hormone receptor 0.0044 0.0099 0.0233
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0135 0.0981 0.096
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0044 0.0099 0.023
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0044 0.0099 0.0076
Trypanosoma cruzi protein farnesyltransferase, putative 0.0364 0.3185 0.8824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0099 0.023
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0099 0.063 0.0608
Loa Loa (eye worm) melatonin receptor type 1A 0.0044 0.0099 0.0303
Trypanosoma cruzi protein farnesyltransferase, putative 0.0364 0.3185 0.8824
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0045 0.0139
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus multilocularis allatostatin A receptor 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Echinococcus multilocularis G-protein coupled receptor, putative 0.0044 0.0099 0.0076
Brugia malayi sulfakinin receptor protein 0.0044 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0044 0.0099 0.0233
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Echinococcus granulosus neuropeptide receptor 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0364 0.3185 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0044 0.0099 0.0076
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0099 0.0076
Schistosoma mansoni biogenic amine receptor 0.0044 0.0099 0.023
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0364 0.3185 0.9753
Echinococcus granulosus fmrfamide receptor 0.0044 0.0099 0.0076
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0099 0.0076
Echinococcus granulosus orexin receptor type 2 0.0044 0.0099 0.0076
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0373 0.3265 0.91
Brugia malayi ORL1-like opioid receptor 0.0044 0.0099 0.0233
Schistosoma mansoni amine GPCR 0.0044 0.0099 0.023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Brugia malayi Dopamine receptor 0.0044 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0135 0.0981 0.096
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Schistosoma mansoni amine GPCR 0.0044 0.0099 0.023
Brugia malayi G-protein coupled receptor 0.0044 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Schistosoma mansoni neuropeptide receptor 0.0044 0.0099 0.023
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0135 0.0981 0.3081
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0135 0.0981 0.2919
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0044 0.0099 0.0233
Echinococcus granulosus G protein coupled receptor 139 0.0044 0.0099 0.0076
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.04 0.3526 0.4376
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0044 0.0099 0.023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0191 0.1514 0.4637
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0099 0.0076
Echinococcus multilocularis somatostatin receptor 0.0044 0.0099 0.0076
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0044 0.0099 0.023
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0135 0.0981 0.1215
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0099 0.023
Echinococcus granulosus 7tm_1 domain containing protein 0.0044 0.0099 0.0076
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0099 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0044 0.0099 0.0303
Echinococcus granulosus serotonin receptor 0.0044 0.0099 0.0076
Brugia malayi Tachykinin-like peptides receptor 99D 0.0044 0.0099 0.0233
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0099 0.0076
Brugia malayi putative neuropeptide receptor 0.0044 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0099 0.063 0.1928
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0099 0.063 0.1846
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0099 0.0076
Leishmania major lanosterol synthase, putative 0.0301 0.2574 0.7851
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0135 0.0981 0.1377
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0135 0.0981 0.096
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi Serotonin receptor 0.0044 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0099 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0135 0.0981 0.1215
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0099 0.063 0.187
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0044 0.0099 0.0303
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus neuropeptide s receptor 0.0044 0.0099 0.0076
Brugia malayi Cytochrome P450 family protein 0.0054 0.02 0.0543
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1073 1 1
Leishmania major geranylgeranyltransferase, putative 0.0099 0.063 0.1797
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0044 0.0099 0.0303
Schistosoma mansoni opsin-like receptor 0.0044 0.0099 0.023
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0266 0.2234 0.6277
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0364 0.3185 0.3169
Loa Loa (eye worm) hypothetical protein 0.0191 0.1514 0.4637
Schistosoma mansoni hypothetical protein 0.0044 0.0099 0.023
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0364 0.3185 1
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Brugia malayi G protein-coupled receptor 0.0044 0.0099 0.0233
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0044 0.0099 0.0303
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0099 0.063 0.1917
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0099 0.023
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0099 0.023
Schistosoma mansoni hypothetical protein 0.0169 0.1304 0.3901
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0135 0.0981 0.3081
Mycobacterium ulcerans epoxide hydrolase EphA 0.0318 0.2739 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0099 0.0076
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.0099 0.023
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0045 0.0068
Brugia malayi AKH receptor 0.0044 0.0099 0.0233
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0135 0.0981 0.1377
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0039 0.0052 0.0029
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi G-protein coupled receptor 0.0044 0.0099 0.0233
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0099 0.023
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0044 0.0099 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus neuropeptide receptor A26 0.0044 0.0099 0.0076
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0044 0.0099 0.0076
Echinococcus multilocularis geminin 0.0169 0.1304 0.1284
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0099 0.0076
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0099 0.063 0.1976
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0044 0.0099 0.0076
Echinococcus multilocularis serotonin receptor 0.0191 0.1514 0.1494
Schistosoma mansoni biogenic amine (5HT) receptor 0.0191 0.1514 0.4541
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0135 0.0981 0.1377
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0044 0.0099 0.0303
Schistosoma mansoni amine GPCR 0.0044 0.0099 0.023
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Schistosoma mansoni biogenic amine receptor 0.0044 0.0099 0.023
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0044 0.0099 0.023
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0044 0.0099 0.0076
Schistosoma mansoni amine GPCR 0.0377 0.3306 1
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0099 0.0076
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0099 0.023
Echinococcus granulosus 7TM GPCR rhodopsin 0.0044 0.0099 0.0076
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0135 0.0981 0.2893
Echinococcus granulosus g-protein coupled receptor 0.0044 0.0099 0.0076
Brugia malayi larval opioid receptor 0.0044 0.0099 0.0233
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0099 0.063 0.1846
Brugia malayi neuropeptide F receptor 0.0044 0.0099 0.0233
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0099 0.063 0.0608
Schistosoma mansoni biogenic amine receptor 0.0044 0.0099 0.023
Echinococcus granulosus alpha 1A adrenergic receptor 0.0044 0.0099 0.0076
Brugia malayi hypothetical protein 0.0044 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0364 0.3185 0.9631
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0135 0.0981 0.3006
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Brugia malayi neuropeptide F receptor 0.0044 0.0099 0.0233
Brugia malayi putative neuropeptide receptor NPR1 0.0044 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus granulosus dro:myosuppressin receptor 0.0044 0.0099 0.0076
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0135 0.0981 0.1215
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0099 0.0303
Loa Loa (eye worm) hypothetical protein 0.0191 0.1511 0.4629
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0364 0.3185 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0099 0.023
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Loa Loa (eye worm) hypothetical protein 0.0044 0.0099 0.0303
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0099 0.063 0.0608
Mycobacterium tuberculosis Possible exported protein 0.0505 0.4537 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.72 uM kg-1 Evaluated for receptor mediated feedback inhibition of 5-HTP formation in hemisphere of rat brain when administered subcutaneously ChEMBL. 3336037
ED50 (functional) = 0.72 uM kg-1 Evaluated for receptor mediated feedback inhibition of 5-HTP formation in hemisphere of rat brain when administered subcutaneously ChEMBL. 3336037
ED50 (functional) = 0.93 uM kg-1 Evaluated for receptor mediated feedback inhibition of 5-HTP formation in limbic tissue of rat brain when administered subcutaneously ChEMBL. 3336037
ED50 (functional) = 0.93 uM kg-1 Evaluated for receptor mediated feedback inhibition of 5-HTP formation in limbic tissue of rat brain when administered subcutaneously ChEMBL. 3336037

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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