TDR Targets

Basic information

Technical information

TDR Targets ID: 307877
Name: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[3-hydroxy-4 -(3-methylphenyl)sulfanylbutyl]cyclopentyl]he ptanoic acid
MW: 424.594 | Formula: C23H36O5S
H donors: 4 H acceptors: 5 LogP: 4.14 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: OC(CSc1cccc(c1)C)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O
InChi: 1S/C23H36O5S/c1-16-7-6-8-18(13-16)29-15-17(24)11-12-20-19(21(25)14-22(20)26)9-4-2-3-5-10-23(27)28/h6-8,13,17,19-22,24-26H,2-5,9-12,14-15H2,1H3,(H,27,28)/t17?,19-,20-,21+,22-/m1/s1
InChiKey: JQFLCIIQNZIBOE-ONFJWMFVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[3-hydroxy-4-(m-tolylsulfanyl)butyl]cyclopentyl]heptanoic acid
7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[3-hydroxy-4-(m-tolylthio)butyl]cyclopentyl]heptanoic acid
7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[3-hydroxy-4-(3-methylphenyl)sulfanyl-butyl]cyclopentyl]heptanoic acid
7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[3-hydroxy-4-(m-tolylthio)butyl]cyclopentyl]enanthic acid
7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[3-hydroxy-4-[(3-methylphenyl)thio]butyl]cyclopentyl]heptanoic acid
7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[3-hydroxy-4-[(3-methylphenyl)thio]butyl]cyclopentyl]enanthic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prostaglandin F receptor (FP)	Starlite/ChEMBL	References
Homo sapiens	prostaglandin E receptor 1 (subtype EP1), 42kDa	Starlite/ChEMBL	References
Homo sapiens	prostaglandin E receptor 4 (subtype EP4)	Starlite/ChEMBL	References
Homo sapiens	prostaglandin E receptor 2 (subtype EP2), 53kDa	Starlite/ChEMBL	References
Homo sapiens	prostaglandin E receptor 3 (subtype EP3)	Starlite/ChEMBL	References
Homo sapiens	prostaglandin I2 (prostacyclin) receptor (IP)	Starlite/ChEMBL	References
Homo sapiens	thromboxane A2 receptor	Starlite/ChEMBL	References
Homo sapiens	prostaglandin D2 receptor (DP)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	rhodopsin orphan GPCR	prostaglandin D2 receptor (DP)	359 aa	312 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	cathepsin D (A01 family)	0.0282	0.3021	0.3021
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Toxoplasma gondii	aspartyl protease ASP1	0.0096	0.0851	0.0851
Brugia malayi	putative neuropeptide receptor NPR1	0.0023	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Schistosoma mansoni	amine GPCR	0.0023	0.0004	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0004	0.0004
Plasmodium falciparum	plasmepsin VI	0.0096	0.0851	0.0851
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0023	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	TYRA-2 protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Schistosoma mansoni	opsin-like receptor	0.0023	0.0004	0.0004
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0591	0.6632	0.6319
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0239	0.2521	0.2521
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0239	0.2521	0.2521
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0239	0.2521	0.2518
Loa Loa (eye worm)	Ras protein let-60	0.0591	0.6632	0.6632
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	GnHR receptor homolog	0.0023	0.0004	0.0004
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0641	0.7216	0.7216
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0367	0.4021	0.4021
Plasmodium vivax	geranylgeranyltransferase, putative	0.0239	0.2521	0.2521
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0239	0.2521	0.1826
Trypanosoma brucei	lanosterol synthase	0.0762	0.8623	0.8159
Onchocerca volvulus		0.0023	0.0004	0.0011
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0004	0.0004
Leishmania major	lanosterol synthase, putative	0.0523	0.5839	0.4437
Giardia lamblia	Prenyltransferase	0.088	1	1
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0744	0.8415	0.8414
Onchocerca volvulus		0.0023	0.0004	0.0011
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0004	0.0004
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0367	0.4021	0.2005
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0367	0.4021	0.2005
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0744	0.8415	0.7881
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Onchocerca volvulus		0.0023	0.0004	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	Dopamine receptor	0.0023	0.0004	0.0004
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0239	0.2521	0.2518
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0239	0.2521	0.2521
Trypanosoma brucei	hypothetical protein, conserved	0.0367	0.4021	0.2005
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0367	0.4021	0.3465
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0023	0.0004	0.0004
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0023	0.0004	0.0011
Leishmania major	farnesyltransferase beta subunit	0.088	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0004	0.0004
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0023	0.0004	0.0004
Schistosoma mansoni	cathepsin D (A01 family)	0.0282	0.3021	0.3021
Trypanosoma cruzi	protein farnesyltransferase, putative	0.088	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	follicle stimulating hormone receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0744	0.8415	0.8415
Loa Loa (eye worm)	hypothetical protein	0.0591	0.6632	0.6632
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	amine GPCR	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Giardia lamblia	Rab geranylgeranyltransferase	0.0744	0.8415	0.7881
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0367	0.4021	0.2005
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0851	0.0851
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0096	0.0851	0.0851
Trypanosoma cruzi	lanosterol synthase, putative	0.0762	0.8623	0.8159
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0004	0.0004
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0239	0.2521	0.2521
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.088	1	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0004	0.0004
Toxoplasma gondii	hypothetical protein	0.0367	0.4021	0.4021
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0004	0.0004
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0367	0.4021	0.2005
Onchocerca volvulus		0.0023	0.0004	0.0011
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0744	0.8415	0.8267
Brugia malayi	RE15519p	0.0023	0.0004	0.0004
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.088	1	1
Brugia malayi	larval opioid receptor	0.0023	0.0004	0.0004
Trypanosoma cruzi	protein farnesyltransferase, putative	0.088	1	1
Onchocerca volvulus		0.0023	0.0004	0.0011
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.088	1	1
Onchocerca volvulus		0.0023	0.0004	0.0011
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0239	0.2521	0.2521
Schistosoma mansoni	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0023	0.0004	0.0004
Onchocerca volvulus		0.0367	0.4021	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Trichomonas vaginalis	dexras1, putative	0.0591	0.6632	0.6319
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0377	0.4131	0.3585
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0591	0.6632	0.6319
Schistosoma mansoni	myosin xvIII	0.0023	0.0004	0.0004
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0744	0.8415	0.8415
Onchocerca volvulus		0.0023	0.0004	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Onchocerca volvulus		0.0023	0.0004	0.0011
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0367	0.4021	0.2005
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0744	0.8415	0.8267
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0367	0.4021	0.2005
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.0004	0.0004
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0744	0.8415	0.8414
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.088	1	1
Schistosoma mansoni	histamine h1 receptor	0.0023	0.0004	0.0004
Brugia malayi	Serotonin receptor	0.0023	0.0004	0.0004
Trypanosoma cruzi	hypothetical protein, conserved	0.0367	0.4021	0.2005
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0367	0.4021	0.2005
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0004	0.0004
Plasmodium vivax	aspartyl proteinase, putative	0.0096	0.0851	0.0851
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.088	1	1
Onchocerca volvulus		0.0023	0.0004	0.0011
Plasmodium falciparum	plasmepsin II	0.0096	0.0851	0.0851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0004	0.0004
Entamoeba histolytica	Ras family GTPase	0.0591	0.6632	0.5497
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0096	0.0851	0.0851
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.088	1	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0023	0.0004	0.0004
Brugia malayi	Melatonin receptor type 1A	0.0023	0.0004	0.0004
Toxoplasma gondii	hypothetical protein	0.0377	0.4131	0.4131
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0367	0.4021	0.4018
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	G-protein coupled receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.088	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0023	0.0004	0.0004
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.088	1	1
Loa Loa (eye worm)	hypothetical protein	0.0239	0.2521	0.2521
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0023	0.0004	0.0004
Giardia lamblia	Rab geranylgeranyltransferase	0.0367	0.4021	0.2005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Trichomonas vaginalis	rap1 and, putative	0.0591	0.6632	0.6319
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.088	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0023	0.0004	0.0004
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0367	0.4021	0.4018
Schistosoma mansoni	hypothetical protein	0.0023	0.0004	0.0004
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0367	0.4021	0.4021
Schistosoma mansoni	opsin-like receptor	0.0023	0.0004	0.0004
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0239	0.2521	0.2521
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0023	0.0004	0.0004
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0367	0.4021	0.4021
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0744	0.8415	0.8415
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.088	1	1
Brugia malayi	Ras-related protein R-Ras2	0.0591	0.6632	0.6632
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0239	0.2521	0.2521
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Plasmodium falciparum	plasmepsin IV	0.0096	0.0851	0.0851
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0239	0.2521	0.1826
Onchocerca volvulus		0.0023	0.0004	0.0011
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0004	0.0004
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0744	0.8415	0.8415
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0004	0.0004
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.088	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0367	0.4021	0.4021
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0023	0.0004	0.0004
Trichomonas vaginalis	ral, putative	0.0591	0.6632	0.6319
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0744	0.8415	0.8415
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0023	0.0004	0.0004
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0023	0.0004	0.0004
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0004	0.0004
Brugia malayi	putative neuropeptide receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0239	0.2521	0.2521
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0239	0.2521	0.2518
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0744	0.8415	0.8415
Onchocerca volvulus		0.0023	0.0004	0.0011
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0023	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0004	0.0004
Trichomonas vaginalis	rheb, putative	0.0591	0.6632	0.6319
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.088	1	1
Brugia malayi	ORL1-like opioid receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0239	0.2521	0.2521
Brugia malayi	G protein-coupled receptor	0.0023	0.0004	0.0004
Plasmodium vivax	plasmepsin IV, putative	0.0096	0.0851	0.0851
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0023	0.0004	0.0004
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0004	0.0004
Brugia malayi	Dopamine receptor protein 1	0.0023	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Onchocerca volvulus		0.0023	0.0004	0.0011
Schistosoma mansoni	growth hormone secretagogue receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	opsin-like receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Onchocerca volvulus		0.0023	0.0004	0.0011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0004	0.0004
Brugia malayi	sulfakinin receptor protein	0.0023	0.0004	0.0004
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0096	0.0851	0.0847
Schistosoma mansoni	neuropeptide f receptor 76f	0.0023	0.0004	0.0004
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0744	0.8415	0.8267
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0023	0.0004	0.0011
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0004	0.0004
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0096	0.0851	0.0847
Schistosoma mansoni	amine GPCR	0.0023	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0023	0.0004	0.0004
Entamoeba histolytica	ras-1, putative	0.0591	0.6632	0.5497
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0367	0.4021	0.4018
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Onchocerca volvulus		0.0023	0.0004	0.0011
Brugia malayi	AKH receptor	0.0023	0.0004	0.0004
Onchocerca volvulus		0.0023	0.0004	0.0011
Brugia malayi	Ras protein let-60	0.0591	0.6632	0.6632
Brugia malayi	G-protein coupled receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.088	1	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0096	0.0851	0.0851
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0762	0.8623	0.5
Echinococcus granulosus	ras gtpase	0.0591	0.6632	0.6631
Onchocerca volvulus		0.0023	0.0004	0.0011
Schistosoma mansoni	amine GPCR	0.0023	0.0004	0.0004
Entamoeba histolytica	Ras family GTPase	0.0591	0.6632	0.5497
Brugia malayi	neuropeptide F receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Trypanosoma cruzi	hypothetical protein, conserved	0.0367	0.4021	0.2005
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0239	0.2521	0.2521
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.088	1	1
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.088	1	1
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0239	0.2521	0.1826
Brugia malayi	Serotonin receptor	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0239	0.2521	0.2521
Loa Loa (eye worm)	melatonin receptor type 1A	0.0023	0.0004	0.0004
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0367	0.4021	0.4021
Trypanosoma cruzi	lanosterol synthase, putative	0.0762	0.8623	0.8159
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0004	0.0004
Brugia malayi	Dopamine receptor protein 2	0.0023	0.0004	0.0004
Brugia malayi	neuropeptide F receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	adenoreceptor	0.0023	0.0004	0.0004
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0239	0.2521	0.2521
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Schistosoma mansoni	amine GPCR	0.0023	0.0004	0.0004
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0367	0.4021	0.2005
Echinococcus multilocularis	ras gtpase	0.0591	0.6632	0.6631
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0367	0.4021	0.4018
Onchocerca volvulus		0.0023	0.0004	0.0011
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0023	0.0004	0.0004
Plasmodium falciparum	plasmepsin I	0.0096	0.0851	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0004	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0023	0.0004	0.0004

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 63 nM	Affinity for human Prostanoid FP receptor expressed in COS-7 cells	ChEMBL.	10715159
IC50 (binding)	= 63 nM	Affinity for human Prostanoid FP receptor expressed in COS-7 cells	ChEMBL.	10715159
IC50 (binding)	= 4600 nM	Affinity for Prostanoid EP1 receptor expressed in COS-7 cells.	ChEMBL.	10715159
IC50 (binding)	= 4600 nM	Affinity for Prostanoid EP1 receptor expressed in COS-7 cells.	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostanoid EP3 receptor expressed in CHO cell line	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostanoid EP4 receptor expressed in CHO cells	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostanoid TP receptor expressed in CHO cells	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for human Prostaglandin D2 receptor expressed in HEK-293 cells	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostaglandin I2 receptor expressed in CHO cells	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostanoid EP3 receptor expressed in CHO cell line	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostanoid EP4 receptor expressed in CHO cells	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostanoid TP receptor expressed in CHO cells	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for human Prostaglandin D2 receptor expressed in HEK-293 cells	ChEMBL.	10715159
IC50 (binding)	> 10000 nM	Affinity for Prostaglandin I2 receptor expressed in CHO cells	ChEMBL.	10715159

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL176692
PubChem: 10741017

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 307877