Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin beta subunit | 0.0176 | 0.237 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0121 | 0.1461 | 0.0563 |
Trichomonas vaginalis | chromobox protein, putative | 0.0055 | 0.036 | 0.2077 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0787 | 0.1754 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0121 | 0.1461 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1445 | 0.3252 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0205 | 0.0429 |
Echinococcus multilocularis | integrin beta 2 | 0.0222 | 0.3122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1461 | 0.3289 |
Trichomonas vaginalis | chromobox protein, putative | 0.0055 | 0.036 | 0.2077 |
Trypanosoma brucei | p-glycoprotein | 0.0121 | 0.1461 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0055 | 0.036 | 0.1457 |
Brugia malayi | multidrug resistance related protein 1 | 0.0121 | 0.1461 | 0.2988 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0121 | 0.1461 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0222 | 0.3122 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 4 | 0.0093 | 0.0995 | 0.2297 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0121 | 0.1461 | 0.2988 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1282 | 0.2882 |
Schistosoma mansoni | multidrug resistance protein | 0.0121 | 0.1461 | 0.6137 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0121 | 0.1461 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 4 | 0.0093 | 0.0995 | 0.2297 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Leishmania major | pentamidine resistance protein 1 | 0.0121 | 0.1461 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0055 | 0.036 | 0.0368 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0121 | 0.1461 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0121 | 0.1461 | 0.3985 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0637 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.4054 | 0.9197 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.011 | 0.1282 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1351 | 0.304 |
Schistosoma mansoni | multidrug resistance protein | 0.0121 | 0.1461 | 0.6137 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0121 | 0.1461 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0197 | 0.2713 | 0.0066 |
Loa Loa (eye worm) | multidrug resistance-associated protein | 0.0094 | 0.1011 | 0.2264 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0121 | 0.1461 | 0.3985 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0121 | 0.1461 | 0.3985 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0138 | 0.1733 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.4054 | 0.9197 |
Schistosoma mansoni | multidrug resistance protein | 0.0121 | 0.1461 | 0.6137 |
Echinococcus multilocularis | integrin alpha ps | 0.0065 | 0.0537 | 0.064 |
Schistosoma mansoni | multidrug resistance protein | 0.0121 | 0.1461 | 0.6137 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0121 | 0.1461 | 0.3289 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0033 | 0 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0121 | 0.1461 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0055 | 0.036 | 0.0781 |
Schistosoma mansoni | integrin alpha-ps | 0.0065 | 0.0537 | 0.2209 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0138 | 0.1733 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0121 | 0.1461 | 0.5 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0045 | 0.0205 | 0.0429 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0225 | 0.3181 | 0.7208 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0121 | 0.1461 | 0.0563 |
Echinococcus granulosus | integrin alpha 3 | 0.0112 | 0.1307 | 0.3427 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0121 | 0.1461 | 0.0563 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0121 | 0.1461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.4054 | 0.9197 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0299 | 0.4406 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0121 | 0.1461 | 0.0563 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0138 | 0.1733 | 1 |
Leishmania major | p-glycoprotein e | 0.0121 | 0.1461 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0055 | 0.036 | 0.1457 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0121 | 0.1461 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0065 | 0.0537 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1461 | 0.3289 |
Echinococcus multilocularis | integrin alpha ps | 0.0065 | 0.0537 | 0.064 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0278 | 0.4054 | 0.9197 |
Trypanosoma brucei | multidrug resistance protein E | 0.0121 | 0.1461 | 0.5 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0637 | 1 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0299 | 0.4406 | 1 |
Echinococcus multilocularis | integrin alpha 3 | 0.0112 | 0.1307 | 0.3427 |
Schistosoma mansoni | integrin alpha | 0.0146 | 0.1871 | 0.7881 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0121 | 0.1461 | 0.3985 |
Leishmania major | ABC-thiol transporter | 0.0121 | 0.1461 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0278 | 0.4054 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0146 | 0.1871 | 0.3965 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 50 uM kg-1 | Evaluated for receptor mediated feedback inhibition of 5-HTP formation in limbic tissue of rat brain when administered subcutaneously | ChEMBL. | 3336037 |
ED50 (functional) | > 50 uM kg-1 | Evaluated for receptor mediated feedback inhibition of 5-HTP formation in striatum tissue of rat brain when administered subcutaneously | ChEMBL. | 3336037 |
ED50 (functional) | > 50 uM kg-1 | Evaluated for receptor mediated feedback inhibition of 5-HTP formation in hemisphere of rat brain when administered subcutaneously | ChEMBL. | 3336037 |
ED50 (functional) | > 50 uM kg-1 | Evaluated for receptor mediated feedback inhibition of 5-HTP formation in limbic tissue of rat brain when administered subcutaneously | ChEMBL. | 3336037 |
ED50 (functional) | > 50 uM kg-1 | Evaluated for receptor mediated feedback inhibition of 5-HTP formation in striatum tissue of rat brain when administered subcutaneously | ChEMBL. | 3336037 |
ED50 (functional) | > 50 uM kg-1 | Evaluated for receptor mediated feedback inhibition of 5-HTP formation in hemisphere of rat brain when administered subcutaneously | ChEMBL. | 3336037 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.