Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ABC transporter transmembrane region family protein | 0.0014 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0014 | 0.0448 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0014 | 0.0448 | 0.5 |
Giardia lamblia | MRP-like ABC transporter | 0.0014 | 0.0448 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0014 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0014 | 0.0448 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0084 | 1 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0014 | 0.0448 | 0.5 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0014 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 1 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0014 | 0.0448 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0014 | 0.0448 | 0.5 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0014 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0014 | 0.0448 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0084 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0014 | 0.0448 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0014 | 0.0448 | 1 |
Leishmania major | p-glycoprotein e | 0.0014 | 0.0448 | 0.5 |
Trypanosoma brucei | multidrug resistance protein E | 0.0014 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0014 | 0.0448 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0014 | 0.0448 | 0.5 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0014 | 0.0448 | 0.0433 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0014 | 0.0448 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0014 | 0.0448 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0014 | 0.0448 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0014 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0433 | 0.0418 |
Entamoeba histolytica | hypothetical protein | 0.0014 | 0.0448 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.0014 | 0.0448 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0014 | 0.0448 | 0.5 |
Trypanosoma brucei | p-glycoprotein | 0.0014 | 0.0448 | 0.5 |
Brugia malayi | multidrug resistance related protein 1 | 0.0014 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0448 | 0.0433 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0014 | 0.0448 | 1 |
Giardia lamblia | ABC transporter, putative | 0.0014 | 0.0448 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0014 | 0.0448 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0014 | 0.0448 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0014 | 0.0448 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0014 | 0.0448 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0014 | 0.0448 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0448 | 0.0433 |
Leishmania major | pentamidine resistance protein 1 | 0.0014 | 0.0448 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED20 (functional) | = 0.022 mM kg-1 | Hypoglycemic activity by lowering blood glucose in normal rats by 20% after oral administration. | ChEMBL. | 6864736 |
ED20 (functional) | = 0.14 mM kg-1 | Hypoglycemic activity by lowering blood glucose in streptozotocin-diabetic rats by 20% after oral administration. | ChEMBL. | 6864736 |
ED50 (functional) | = 0.13 mM kg-1 | Hypoglycemic activity by lowering blood glucose in normal rats by 50% after oral administration. | ChEMBL. | 6864736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.