Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0008 | 0.0081 | 0.0081 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0081 | 0.0081 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0008 | 0.0081 | 0.0081 |
Echinococcus multilocularis | multidrug and toxin extrusion protein 2 | 0.0077 | 0.3837 | 0.3837 |
Giardia lamblia | Na+ driven multidrug efflux pump | 0.0007 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.3837 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0008 | 0.0081 | 0.0081 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0081 | 0.0081 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.1905 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.3837 | 1 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0008 | 0.0081 | 0.0081 |
Echinococcus multilocularis | Multi antimicrobial extrusion protein MatE | 0.007 | 0.3469 | 0.3469 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0008 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.1905 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.3837 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.029 | 0.029 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.3837 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.029 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.029 | 0.1145 |
Mycobacterium ulcerans | DNA-damage-inducible protein F DinF | 0.0007 | 0 | 0.5 |
Trypanosoma brucei | MATE efflux family protein, putative | 0.0077 | 0.3837 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.029 | 0.029 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0008 | 0.0081 | 0.0081 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.029 | 0.1145 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0081 | 0.0081 |
Echinococcus granulosus | multidrug and toxin extrusion protein 2 | 0.0077 | 0.3837 | 0.3837 |
Plasmodium falciparum | multidrug efflux pump, putative | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0008 | 0.0081 | 0.0081 |
Giardia lamblia | Na+ driven multidrug efflux pump | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0008 | 0.0081 | 0.0081 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0008 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1605 | 0.8354 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.1905 | 0.1905 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.029 | 0.029 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.1755 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.029 | 0.029 |
Trypanosoma brucei | membrane transporter protein, putative | 0.0077 | 0.3837 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0008 | 0.0081 | 0.0081 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Trypanosoma cruzi | membrane transporter protein, putative | 0.0077 | 0.3837 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.1905 | 0.1905 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.2114 | 0.2114 |
Schistosoma mansoni | hypothetical protein | 0.019 | 1 | 1 |
Trypanosoma brucei | membrane transporter protein, putative | 0.0077 | 0.3837 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.029 | 0.029 |
Giardia lamblia | Na+ driven multidrug efflux pump | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0077 | 0.3837 | 0.3837 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0008 | 0.0081 | 0.0463 |
Echinococcus multilocularis | geminin | 0.019 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.3837 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.3837 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.2114 | 0.2114 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.3837 | 1 |
Treponema pallidum | hypothetical protein | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0081 | 0.0081 |
Trypanosoma brucei | membrane transporter protein, putative | 0.0077 | 0.3837 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0008 | 0.0081 | 0.0081 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0008 | 0.0081 | 0.0081 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.1755 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0081 | 0.0081 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0008 | 0.0081 | 0.0463 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reversal (functional) | = 0 % | Ability (% reversal in rats) to reverse electroconvulsive shock-induced amnesia in rodents at a dose of 0.10 (mg/kg) (following intramuscular dosing) | ChEMBL. | 3712386 |
Reversal (functional) | = 0 % | Ability(%reversal in rats) to reverse electroconvulsive shock-induced amnesia in rodents at a dose of 0.010 (mg/kg) administered intramuscularly (im) | ChEMBL. | 3712386 |
Reversal (functional) | = 33 % | Ability (% reversal in rats) to reverse electroconvulsive shock-induced amnesia in rodents at a dose of 0.0010 (mg/kg) (following i.m. administration) | ChEMBL. | 3712386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.