Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.069 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.069 | 0.5 |
Brugia malayi | cell division control protein 2 homolog | 0.0052 | 0.069 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.069 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 0.069 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.069 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0052 | 0.069 | 0.069 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0027 | 0 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 0.069 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0385 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.069 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0052 | 0.069 | 0.069 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.069 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.069 | 0.0719 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0674 | 0.9774 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 0.069 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.069 | 0.069 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.069 | 0.0719 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0052 | 0.069 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0052 | 0.069 | 0.069 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0052 | 0.069 | 0.0719 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.069 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.069 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.069 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0027 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.069 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.069 | 0.069 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0052 | 0.069 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 0.069 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.069 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.069 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0052 | 0.069 | 0.069 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.069 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 0.069 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.037 | 0.9594 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 0.069 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0052 | 0.069 | 0.0719 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.069 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.028 uM | Inhibitory activity of the compound against cyclin-dependent kinase 1 (CDK1) was determined | ChEMBL. | 9990463 |
IC50 (binding) | = 0.028 uM | Inhibitory activity of the compound against cyclin-dependent kinase 1 (CDK1) was determined | ChEMBL. | 9990463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.