Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 alpha | References | |
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein kinase shaggy | 0.0116 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0116 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase shaggy | 0.0116 | 0 | 0.5 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0116 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0645 | 0.9834 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0 | 0.5 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0116 | 0 | 0.5 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0116 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0645 | 0.9834 | 1 |
Brugia malayi | intracellular kinase | 0.0116 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0116 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0654 | 1 | 0.5 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0116 | 0 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0654 | 1 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0116 | 0 | 0.5 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0437 | 0.5964 | 0.4101 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0645 | 0.9834 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0116 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0116 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0116 | 0 | 0.5 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0116 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0116 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 uM | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | ChEMBL. | 11881998 |
IC50 (binding) | = 5 uM | Inhibition of rabbit GSK3 | ChEMBL. | 16279768 |
IC50 (binding) | = 5 uM | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | ChEMBL. | 11881998 |
IC50 (binding) | = 5 uM | Inhibition of rabbit GSK3 | ChEMBL. | 16279768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.