Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 3 (neuronal) | Starlite/ChEMBL | References |
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Rattus norvegicus | Neuronal acetylcholine receptor; alpha3/beta4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0146 | 0.5033 | 0.5033 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0174 | 0.6645 | 0.6645 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0182 | 0.7127 | 0.7095 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0182 | 0.7127 | 0.7127 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0146 | 0.5033 | 0.5033 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0146 | 0.5033 | 0.4977 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.006 | 0.0112 | 0.0112 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0174 | 0.6645 | 0.6607 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0146 | 0.5033 | 0.5033 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.006 | 0.0112 | 0.0112 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0146 | 0.5033 | 0.4977 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.006 | 0.0112 | 0.0112 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.006 | 0.0112 | 0.0112 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.006 | 0.0112 | 0.0112 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0146 | 0.5033 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0146 | 0.5033 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.006 | 0.0112 | 0.0112 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.006 | 0.0112 | 0.0112 |
Onchocerca volvulus | Putative nachr subunit | 0.0146 | 0.5033 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.006 | 0.0112 | 0.0112 |
Echinococcus multilocularis | nAChR subunit | 0.006 | 0.0112 | 0.0112 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0198 | 0.8069 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.006 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.5033 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0146 | 0.5033 | 0.4977 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0232 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.6 nM | Inhibition of [3H]-Epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 15771418 |
Ki (binding) | = 1.6 nM | Inhibition of [3H]-Epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 15771418 |
Ki (binding) | = 2.5 nM | Inhibition of [3H]-Epibatidine binding to Nicotinic acetylcholine receptor alpha2-beta2 | ChEMBL. | 15771418 |
Ki (binding) | = 8.2 nM | Inhibition of [3H]-Epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2 | ChEMBL. | 15771418 |
Ki (binding) | = 8.2 nM | Inhibition of [3H]-Epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2 | ChEMBL. | 15771418 |
Ki (binding) | = 710 nM | Inhibition of [3H]-Epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta4 | ChEMBL. | 15771418 |
Ki (binding) | = 750 nM | Inhibition of [3H]-Epibatidine binding to Nicotinic acetylcholine receptor alpha2-beta4 | ChEMBL. | 15771418 |
Ki (binding) | = 6800 nM | Inhibition of [3H]-Epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4 | ChEMBL. | 15771418 |
Ki (binding) | = 6800 nM | Inhibition of [3H]-Epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4 | ChEMBL. | 15771418 |
Selectivity (binding) | = 4250 | Selectivity against Nicotinic acetylcholine receptor subtypes alpha3-beta4 and alpha4-beta2 | ChEMBL. | 15771418 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.