Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | Starlite/ChEMBL | References |
Hepatitis C virus genotype 1a (isolate 1) (HCV) | Hepatitis C virus polyprotein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | prolyl endopeptidase | 0.0298 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0207 | 0.5635 | 0.5635 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0207 | 0.5635 | 0.5635 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0298 | 1 | 1 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0127 | 0.1803 | 0.1803 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0127 | 0.1803 | 0.1803 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0127 | 0.1803 | 0.1803 |
Toxoplasma gondii | prolyl endopeptidase | 0.0298 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0298 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0298 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0207 | 0.5635 | 0.5635 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0298 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0127 | 0.1803 | 0.1803 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0298 | 1 | 1 |
Leishmania major | oligopeptidase b | 0.0127 | 0.1803 | 0.1803 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0127 | 0.1803 | 0.1803 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0298 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0127 | 0.1803 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0298 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0127 | 0.1803 | 0.1803 |
Trypanosoma cruzi | oligopeptidase b | 0.0127 | 0.1803 | 0.1803 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0207 | 0.5635 | 0.5635 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0254 | 0.79 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0127 | 0.1803 | 0.5 |
Trypanosoma brucei | oligopeptidase b | 0.0127 | 0.1803 | 0.1803 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Cytotoxicity against Huh7 cells upto 100 uM | ChEMBL. | 16509585 |
EC50 (functional) | = 3.1 uM | Inhibition of replication of HCV 1b BK RNA in Huh7 cells | ChEMBL. | 16509585 |
EC50 (functional) | = 3.1 uM | Inhibition of replication of HCV 1b BK RNA in Huh7 cells | ChEMBL. | 16509585 |
EC50 (binding) | = 9.3 uM | Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase | ChEMBL. | 16509585 |
EC50 (binding) | = 9.3 uM | Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.036 uM | Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving manganese chelation | ChEMBL. | 16509585 |
IC50 (binding) | = 0.036 uM | Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving manganese chelation | ChEMBL. | 16509585 |
IC50 (binding) | = 0.044 uM | Inhibitory activity against HCV 2a BK NS5B deltaC21 RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.044 uM | Inhibitory activity against HCV 2a BK NS5B deltaC21 RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.045 uM | Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.045 uM | Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.048 uM | Inhibitory activity against HCV 3a BK NS5B deltaC21 RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.048 uM | Inhibitory activity against HCV 3a BK NS5B deltaC21 RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.1 uM | Inhibitory concentration of the compound against hepatitis C virus polymerase | ChEMBL. | 15633995 |
IC50 (binding) | = 0.1 uM | Inhibitory concentration of the compound against hepatitis C virus polymerase | ChEMBL. | 15633995 |
IC50 (binding) | = 0.13 uM | Inhibitory activity against HCV 1b BK NS5B RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.13 uM | Inhibitory activity against HCV 1b BK NS5B RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.15 uM | Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.15 uM | Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving magnesium chelation | ChEMBL. | 16509585 |
IC50 (binding) | = 0.15 uM | Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase | ChEMBL. | 16509585 |
IC50 (binding) | = 0.15 uM | Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving magnesium chelation | ChEMBL. | 16509585 |
Log D | = 0.37 | Lipophilicity as measured by LogD at pH 7.4 | ChEMBL. | 16509585 |
pKa | = 6.6 | Dissociation constant, pKa of the compound | ChEMBL. | 16509585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.