Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Enterococcus faecalis (strain ATCC 700802 / V583) | Beta-ketoacyl-ACP synthase III | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K01641 hydroxymethylglutaryl-CoA synthase [EC2.3.3.10], putative | Beta-ketoacyl-ACP synthase III | 321 aa | 271 aa | 22.1 % |
Mycobacterium tuberculosis | Conserved hypothetical protein | Beta-ketoacyl-ACP synthase III | 321 aa | 310 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | adenosylhomocysteinase | 0.0129 | 0.2381 | 0.1474 |
Schistosoma mansoni | adenosine deaminase-related | 0.0085 | 0.1064 | 0.1079 |
Treponema pallidum | adenosine deaminase | 0.0085 | 0.1064 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0129 | 0.2381 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0129 | 0.2381 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0129 | 0.2381 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0129 | 0.2381 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0129 | 0.2381 | 1 |
Brugia malayi | Adenosylhomocysteinase | 0.0129 | 0.2381 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0129 | 0.2381 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1064 | 0.3874 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0085 | 0.1064 | 0.4469 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0129 | 0.2381 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 1 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0129 | 0.2381 | 0.1474 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0129 | 0.2381 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0129 | 0.2381 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0129 | 0.2381 | 0.1474 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0129 | 0.2381 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0085 | 0.1064 | 0.4469 |
Schistosoma mansoni | adenosine deaminase | 0.0085 | 0.1064 | 0.1079 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0085 | 0.1064 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0129 | 0.2381 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0129 | 0.2381 | 0.1474 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0129 | 0.2381 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0129 | 0.2381 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0129 | 0.2381 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.076 | Inhibition of Enterococcus faecalis FabH by FabD/FabH coupled assay | ChEMBL. | 17707951 |
IC50 (binding) | = 8.4 uM | Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III | ChEMBL. | 15743201 |
IC50 (binding) | = 8.4 uM | Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III | ChEMBL. | 15743201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.