Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E synthase | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1192 | 0.4337 | 1 |
Echinococcus multilocularis | protein patched | 0.1046 | 0.3724 | 0.3724 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.2541 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1192 | 0.4337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2541 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.1046 | 0.3724 | 0.3724 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1046 | 0.3724 | 0.3724 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0409 | 0.1049 | 0.1049 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0014 | 0.0014 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.2541 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.2541 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1046 | 0.3724 | 0.3724 |
Brugia malayi | CHE-14 protein | 0.1046 | 0.3724 | 0.3715 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1046 | 0.3724 | 0.3724 |
Loa Loa (eye worm) | hypothetical protein | 0.1046 | 0.3724 | 0.3724 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0163 | 0.0014 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1046 | 0.3724 | 0.3724 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2541 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0938 | 0.3268 | 0.3258 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.2541 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1046 | 0.3724 | 0.3724 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2541 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2541 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.1046 | 0.3724 | 0.3724 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0409 | 0.1049 | 0.1049 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1046 | 0.3724 | 0.3724 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1046 | 0.3724 | 0.3724 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1192 | 0.4337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.0565 | 0.0565 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0409 | 0.1049 | 0.1049 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1192 | 0.4337 | 0.5 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.059 | 0.1807 | 0.1807 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2541 | 1 | 1 |
Onchocerca volvulus | 0.0163 | 0.0014 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.016 uM | Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1) | ChEMBL. | 15953724 |
IC50 (binding) | = 0.016 uM | Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1) | ChEMBL. | 15953724 |
IC50 (binding) | = 0.016 uM | Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assay | ChEMBL. | 21466167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.