Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.193 | 0.193 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.2106 | 0.2106 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.1213 | 0.1213 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0041 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0175 | 0.2791 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0521 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0175 | 0.2791 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0521 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0175 | 0.2791 | 1 |
Brugia malayi | hypothetical protein | 0.0134 | 0.193 | 0.193 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0175 | 0.2791 | 0.2791 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0041 | 0 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0521 | 1 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0521 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0175 | 0.2791 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.2106 | 0.2106 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0041 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.2791 | 0.2791 |
Mycobacterium tuberculosis | Probable peptidase | 0.0041 | 0 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0175 | 0.2791 | 0.2791 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0041 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0041 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0175 | 0.2791 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0521 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0041 | 0 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0041 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0175 | 0.2791 | 0.2791 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.2106 | 0.2106 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0175 | 0.2791 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 90 nM | Inhibitory concentration against 5-lipoxygenase in human whole blood | ChEMBL. | 15686917 |
IC50 (functional) | = 90 nM | Inhibitory concentration against 5-lipoxygenase in human whole blood | ChEMBL. | 15686917 |
IC50 (binding) | = 170 nM | Inhibitory concentration against human 5-lipoxygenase | ChEMBL. | 15686917 |
IC50 (binding) | = 170 nM | Inhibitory concentration against human 5-lipoxygenase | ChEMBL. | 15686917 |
Ki (binding) | = 5.01 nM | Binding affinity for human Histamine H1 receptor in CHO K1 cells | ChEMBL. | 15686917 |
Ki (binding) | = 5.01 nM | Binding affinity for human Histamine H1 receptor in CHO K1 cells | ChEMBL. | 15686917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.