Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E synthase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0409 | 0.1049 | 0.1049 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1046 | 0.3724 | 0.3724 |
Onchocerca volvulus | 0.0163 | 0.0014 | 0.5 | |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.059 | 0.1807 | 0.1807 |
Echinococcus multilocularis | protein dispatched 1 | 0.1046 | 0.3724 | 0.3724 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1192 | 0.4337 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2541 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0014 | 0.0014 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.2541 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1046 | 0.3724 | 0.3724 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1046 | 0.3724 | 0.3724 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2541 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2541 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2541 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.2541 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.2541 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1192 | 0.4337 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0938 | 0.3268 | 0.3258 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1192 | 0.4337 | 1 |
Brugia malayi | CHE-14 protein | 0.1046 | 0.3724 | 0.3715 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1046 | 0.3724 | 0.3724 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1192 | 0.4337 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1046 | 0.3724 | 0.3724 |
Loa Loa (eye worm) | hypothetical protein | 0.1046 | 0.3724 | 0.3724 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1046 | 0.3724 | 0.3724 |
Schistosoma mansoni | patched 1 | 0.1046 | 0.3724 | 0.3724 |
Echinococcus multilocularis | protein patched | 0.1046 | 0.3724 | 0.3724 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1046 | 0.3724 | 0.3724 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0163 | 0.0014 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0409 | 0.1049 | 0.1049 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.2541 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.0565 | 0.0565 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0409 | 0.1049 | 0.1049 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2541 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.