Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0095 | 0.022 | 0.5 | |
Schistosoma mansoni | cathepsin D (A01 family) | 0.1032 | 1 | 1 |
Trypanosoma brucei | N-myristoyltransferase | 0.0175 | 0.1058 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0115 | 0.043 | 0.2347 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0095 | 0.022 | 0.022 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0175 | 0.1058 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.025 | 0.1833 | 0.465 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0175 | 0.1058 | 0.5679 |
Plasmodium vivax | aspartyl proteinase, putative | 0.025 | 0.1833 | 0.465 |
Plasmodium falciparum | plasmepsin I | 0.025 | 0.1833 | 0.465 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0095 | 0.022 | 0.022 |
Leishmania major | N-myristoyl transferase, putative | 0.0175 | 0.1058 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.025 | 0.1833 | 0.465 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0313 | 0.2494 | 1 |
Onchocerca volvulus | 0.0095 | 0.022 | 0.5 | |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.025 | 0.1833 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0175 | 0.1058 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0095 | 0.022 | 0.022 |
Brugia malayi | celfurPC protein | 0.0252 | 0.1862 | 0.7223 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0095 | 0.022 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.022 | 0.0882 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0175 | 0.1058 | 0.2414 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0095 | 0.022 | 0.022 |
Plasmodium falciparum | plasmepsin IX | 0.0427 | 0.369 | 1 |
Echinococcus multilocularis | 0.0252 | 0.1862 | 1 | |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.019 | 0.1213 | 0.4865 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0095 | 0.022 | 0.022 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.019 | 0.1213 | 0.6617 |
Plasmodium falciparum | plasmepsin IV | 0.025 | 0.1833 | 0.465 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.025 | 0.1833 | 0.1833 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0175 | 0.1058 | 0.5 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0095 | 0.022 | 0.022 |
Brugia malayi | proprotein convertase 2 | 0.0197 | 0.1281 | 0.4665 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.022 | 0.0882 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0197 | 0.1281 | 0.4665 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.025 | 0.1833 | 0.465 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.019 | 0.1213 | 0.6617 |
Plasmodium vivax | aspartyl protease, putative | 0.0427 | 0.369 | 1 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0175 | 0.1058 | 0.4241 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0175 | 0.1058 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0427 | 0.369 | 1 |
Giardia lamblia | CDC72 | 0.0175 | 0.1058 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0175 | 0.1058 | 0.5768 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0095 | 0.022 | 0.0882 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.025 | 0.1833 | 0.9845 |
Brugia malayi | endoprotease bli-4 precursor | 0.0313 | 0.2494 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.0175 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.025 | 0.1833 | 0.7352 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0197 | 0.1281 | 0.6877 |
Plasmodium vivax | aspartyl protease, putative | 0.0427 | 0.369 | 1 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0313 | 0.2494 | 0.2494 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0095 | 0.022 | 0.022 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0095 | 0.022 | 0.022 |
Plasmodium falciparum | plasmepsin X | 0.0427 | 0.369 | 1 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.019 | 0.1213 | 0.6515 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0175 | 0.1058 | 0.2414 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0095 | 0.022 | 0.0882 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.1833 | 0.7352 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0136 | 0.0649 | 0.0649 |
Echinococcus granulosus | furin | 0.0313 | 0.2494 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.025 | 0.1833 | 0.465 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.051 | 0.2043 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0197 | 0.1281 | 0.5135 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.2494 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.025 | 0.1833 | 0.7352 |
Plasmodium vivax | plasmepsin IV, putative | 0.025 | 0.1833 | 0.465 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0175 | 0.1058 | 0.4241 |
Brugia malayi | N-myristoyltransferase 2 | 0.0175 | 0.1058 | 0.3684 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5 uM | Bindining affinity for human tachykinin receptor 2 was measured by using [125I]-NKA as radio ligand | ChEMBL. | 15664817 |
Ki (binding) | = 5 uM | Bindining affinity for human tachykinin receptor 2 was measured by using [125I]-NKA as radio ligand | ChEMBL. | 15664817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.