Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin D1 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0276 | 0.096 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0887 | 0.614 | 0.614 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0546 | 0.3245 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0225 | 0.0528 | 0.0528 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0945 | 0.6631 | 0.6631 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1008 | 0.7159 | 0.7159 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0887 | 0.614 | 0.614 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1008 | 0.7159 | 0.7159 |
Schistosoma mansoni | glutamate receptor NMDA | 0.117 | 0.8538 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0225 | 0.0528 | 0.0528 |
Schistosoma mansoni | neuropeptide receptor | 0.0887 | 0.614 | 0.7191 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0225 | 0.0528 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.3245 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1343 | 1 | 1 |
Schistosoma mansoni | cyclin B3 | 0.022 | 0.0486 | 0.0569 |
Echinococcus granulosus | glutamate receptor 2 | 0.0225 | 0.0528 | 0.0528 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.022 | 0.0486 | 0.1498 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0225 | 0.0528 | 0.0528 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0225 | 0.0528 | 0.0528 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.05 | 0.286 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0945 | 0.6631 | 0.6631 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0225 | 0.0528 | 0.0528 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.022 | 0.0486 | 0.0486 |
Echinococcus multilocularis | neuropeptide receptor | 0.0887 | 0.614 | 0.614 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.022 | 0.0486 | 0.0486 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0546 | 0.3245 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0225 | 0.0528 | 0.0528 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.022 | 0.0486 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0276 | 0.096 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0225 | 0.0528 | 0.0528 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0398 | 0.199 | 0.199 |
Chlamydia trachomatis | glutamine binding protein | 0.0276 | 0.096 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0276 | 0.096 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0225 | 0.0528 | 0.0528 |
Schistosoma mansoni | d-amino acid oxidase | 0.0546 | 0.3245 | 0.3801 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.8 uM | Inhibitory concentration against human Cyclin B-cyclin-dependent kinase 1 was observed | ChEMBL. | 15780638 |
IC50 (binding) | = 4.8 uM | Inhibitory concentration against human Cyclin B-cyclin-dependent kinase 1 was observed | ChEMBL. | 15780638 |
IC50 (binding) | = 11.9 uM | Inhibitory concentration against human Cyclin D1-cyclin-dependent kinase 4 was observed | ChEMBL. | 15780638 |
IC50 (binding) | = 11.9 uM | Inhibitory concentration against human Cyclin D1-cyclin-dependent kinase 4 was observed | ChEMBL. | 15780638 |
IC50 (binding) | = 17.73 uM | Inhibitory concentration against human Cyclin E-cyclin-dependent kinase 2 was observed | ChEMBL. | 15780638 |
IC50 (binding) | = 17.73 uM | Inhibitory concentration against human Cyclin E-cyclin-dependent kinase 2 was observed | ChEMBL. | 15780638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.