Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0147 | 0.3984 | 0.3984 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0147 | 0.3984 | 0.3984 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0265 | 0.8457 | 0.8457 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0147 | 0.3984 | 1 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Brugia malayi | beta-lactamase | 0.0042 | 0 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.0147 | 0.3984 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0306 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 305 nM | Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1 | ChEMBL. | 15664844 |
IC50 (functional) | = 305 nM | Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1 | ChEMBL. | 15664844 |
IC50 (functional) | = 1409 nM | Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1 | ChEMBL. | 15664844 |
IC50 (functional) | = 1409 nM | Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1 | ChEMBL. | 15664844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.