Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1605 | 0.6642 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1075 | 0.3423 | 0.5154 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2158 | 1 | 0.5 |
Onchocerca volvulus | 0.1075 | 0.3423 | 0.5 | |
Brugia malayi | Dihydrofolate reductase | 0.1605 | 0.6642 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2158 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2158 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.1605 | 0.6642 | 1 |
Brugia malayi | thymidylate synthase | 0.1075 | 0.3423 | 0.5154 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2158 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2158 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1605 | 0.6642 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1605 | 0.6642 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1605 | 0.6642 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1605 | 0.6642 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1605 | 0.6642 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0512 | 0 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1605 | 0.6642 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1605 | 0.6642 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.49 uM | Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1b Hepatitis C virus | ChEMBL. | 15745800 |
IC50 (binding) | = 1.49 uM | Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1b Hepatitis C virus | ChEMBL. | 15745800 |
IC50 (binding) | = 16.5 uM | Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1a Hepatitis C virus | ChEMBL. | 15745800 |
IC50 (binding) | = 16.5 uM | Inhibition of HCV genotype 1 polymerase | ChEMBL. | 17869118 |
IC50 (binding) | = 16.5 uM | Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of genotype 1a Hepatitis C virus | ChEMBL. | 15745800 |
log(1/IC50) (binding) | = -1.2175 uM | Inhibition of HCV genotype 1 polymerase | ChEMBL. | 17869118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.