Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0462 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0462 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0462 | 1 | 1 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0219 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0219 | 0.2924 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0151 | 0.093 | 0.093 |
Loa Loa (eye worm) | ctsf protein | 0.0219 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0178 | 0.1716 | 0.5868 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0462 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0151 | 0.093 | 0.093 |
Leishmania major | cysteine peptidase A (CPA) | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0219 | 0.2924 | 0.2924 |
Entamoeba histolytica | cysteine protease, putative | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0219 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0462 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin b | 0.0462 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0462 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.2924 | 0.2198 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0178 | 0.1716 | 0.1716 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0219 | 0.2924 | 0.2198 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0462 | 1 | 1 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0178 | 0.1716 | 0.1716 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0219 | 0.2924 | 0.2924 |
Giardia lamblia | Cathepsin B precursor | 0.0178 | 0.1716 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0219 | 0.2924 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0219 | 0.2924 | 0.2924 |
Giardia lamblia | Cathepsin B precursor | 0.0178 | 0.1716 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0219 | 0.2924 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0219 | 0.2924 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0151 | 0.093 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0219 | 0.2924 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0178 | 0.1716 | 0.0866 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0219 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0178 | 0.1716 | 0.5868 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0219 | 0.2924 | 0.2198 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0219 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0151 | 0.093 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0151 | 0.093 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0219 | 0.2924 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0151 | 0.093 | 0.093 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0219 | 0.2924 | 0.2924 |
Loa Loa (eye worm) | cysteine protease | 0.0219 | 0.2924 | 0.2198 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0219 | 0.2924 | 1 |
Plasmodium vivax | vivapain-2 | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0462 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0178 | 0.1716 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0219 | 0.2924 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0219 | 0.2924 | 1 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0219 | 0.2924 | 0.2924 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0151 | 0.093 | 0.3182 |
Loa Loa (eye worm) | fibroinase | 0.0219 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0151 | 0.093 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0151 | 0.093 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0151 | 0.093 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0219 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0219 | 0.2924 | 0.2924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC99 (functional) | = 25 ug ml-1 | In vitro minimum inhibitory concentration of the compound dissolved in DMSO against M. bovis BCG using BACTEC 460 radiometric system | ChEMBL. | 16002282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.