Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0151 | 0.093 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0151 | 0.093 | 0.093 |
Brugia malayi | cathepsin L-like precursor | 0.0151 | 0.093 | 0.093 |
Onchocerca volvulus | Cathepsin F homolog | 0.0219 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0219 | 0.2924 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0462 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0178 | 0.1716 | 0.1716 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0178 | 0.1716 | 0.5868 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0219 | 0.2924 | 0.2924 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0219 | 0.2924 | 0.2198 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0219 | 0.2924 | 0.2924 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0219 | 0.2924 | 0.2924 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0219 | 0.2924 | 0.2924 |
Echinococcus granulosus | cathepsin b | 0.0462 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0219 | 0.2924 | 0.2924 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0219 | 0.2924 | 0.2198 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0219 | 0.2924 | 1 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0151 | 0.093 | 0.093 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0462 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0219 | 0.2924 | 0.2198 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0151 | 0.093 | 0.093 |
Echinococcus multilocularis | cathepsin b | 0.0462 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.2924 | 0.2198 |
Echinococcus granulosus | cathepsin l1 | 0.0151 | 0.093 | 0.093 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0219 | 0.2924 | 0.2924 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0219 | 0.2924 | 0.2924 |
Giardia lamblia | Cathepsin B precursor | 0.0178 | 0.1716 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0151 | 0.093 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0219 | 0.2924 | 0.2924 |
Echinococcus multilocularis | cysteine protease | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0462 | 1 | 1 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0462 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0219 | 0.2924 | 0.2924 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0219 | 0.2924 | 0.2924 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0178 | 0.1716 | 0.1716 |
Echinococcus granulosus | cathepsin l1 | 0.0219 | 0.2924 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Loa Loa (eye worm) | cathepsin B | 0.0178 | 0.1716 | 0.0866 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0151 | 0.093 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0151 | 0.093 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Plasmodium vivax | vivapain-2 | 0.0219 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0219 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0462 | 1 | 1 |
Onchocerca volvulus | 0.0219 | 0.2924 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0178 | 0.1716 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0151 | 0.093 | 0.093 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0219 | 0.2924 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0178 | 0.1716 | 0.5868 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0462 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0219 | 0.2924 | 0.2198 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0178 | 0.1716 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0219 | 0.2924 | 1 |
Echinococcus granulosus | cathepsin b | 0.0462 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0219 | 0.2924 | 0.2924 |
Onchocerca volvulus | Cathepsin L homolog | 0.0219 | 0.2924 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0219 | 0.2924 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0219 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Leishmania major | cathepsin L-like protease | 0.0219 | 0.2924 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0219 | 0.2924 | 0.2924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC99 (functional) | = 25 ug ml-1 | In vitro minimum inhibitory concentration of the compound dissolved in DMSO against M. bovis BCG using BACTEC 460 radiometric system | ChEMBL. | 16002282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.