Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | ABC transporter, putative | 0.003 | 0.0504 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0282 | 1 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.003 | 0.0504 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0504 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.003 | 0.0504 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.003 | 0.0504 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.003 | 0.0504 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.0504 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.003 | 0.0504 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.003 | 0.0504 | 0.0504 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.003 | 0.0504 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.0504 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.003 | 0.0504 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.003 | 0.0504 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.003 | 0.0504 | 1 |
Loa Loa (eye worm) | multidrug resistance-associated protein | 0.0023 | 0.0249 | 0.0249 |
Trypanosoma cruzi | hypothetical protein | 0.0023 | 0.024 | 0.4755 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0504 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.003 | 0.0504 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.003 | 0.0504 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.0504 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0282 | 1 | 1 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.003 | 0.0504 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.003 | 0.0504 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0504 | 0.5 |
Trypanosoma brucei | p-glycoprotein | 0.003 | 0.0504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 1 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.003 | 0.0504 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.003 | 0.0504 | 1 |
Brugia malayi | multidrug resistance related protein 1 | 0.003 | 0.0504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0504 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0495 | 0.0495 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.003 | 0.0504 | 1 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0504 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0504 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.003 | 0.0504 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.003 | 0.0504 | 1 |
Leishmania major | p-glycoprotein e | 0.003 | 0.0504 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.0504 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0504 | 0.0504 |
Trypanosoma brucei | multidrug resistance protein E | 0.003 | 0.0504 | 1 |
Leishmania major | pentamidine resistance protein 1 | 0.003 | 0.0504 | 1 |
Giardia lamblia | ABC transporter, putative | 0.003 | 0.0504 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.003 | 0.0504 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.013 uM | Effective concentration of the compound by cytoprotection activity on glucocorticoid-induced apoptosis in murine thymocytes was determined in vitro | ChEMBL. | 15780606 |
EC50 (functional) | = 0.013 uM | Effective concentration of the compound by cytoprotection activity on glucocorticoid-induced apoptosis in murine thymocytes was determined in vitro | ChEMBL. | 15780606 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15780606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.