Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transglutaminase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0025 | 0.4005 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4005 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | steroid hormone receptor | 0.0025 | 0.4005 | 0.4005 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0107 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0107 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4005 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0025 | 0.4005 | 0.4005 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0025 | 0.4005 | 0.4005 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0025 | 0.4005 | 0.4005 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 0.0107 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0025 | 0.4005 | 0.4005 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0107 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0107 | 0.0268 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4005 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0107 | 0.0268 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0025 | 0.4005 | 0.4005 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4005 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0025 | 0.4005 | 0.4005 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0025 | 0.4005 | 0.4005 |
Schistosoma mansoni | nuclear hormone receptor | 0.0025 | 0.4005 | 0.4005 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0107 | 0.0268 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | nuclear receptor NHR-88 | 0.0025 | 0.4005 | 0.4005 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4005 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0043 | 1 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0025 | 0.4005 | 0.4005 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | nuclear hormone receptor | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0025 | 0.4005 | 0.4005 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0025 | 0.4005 | 0.4005 |
Schistosoma mansoni | coup transcription factor | 0.0025 | 0.4005 | 0.4005 |
Echinococcus multilocularis | Transglutaminase | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0025 | 0.4005 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0025 | 0.4005 | 1 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0043 | 1 | 0.5 |
Onchocerca volvulus | 0.0043 | 1 | 1 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0043 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0025 | 0.4005 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0025 | 0.4005 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0025 | 0.4005 | 0.4005 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0025 | 0.4005 | 0.4005 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0025 | 0.4005 | 0.4005 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0025 | 0.4005 | 0.4005 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0043 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0025 | 0.4005 | 0.4005 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0025 | 0.4005 | 0.4005 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0025 | 0.4005 | 1 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0043 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0025 | 0.4005 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0025 | 0.4005 | 0.4005 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0025 | 0.4005 | 0.4005 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4005 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4005 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0025 | 0.4005 | 0.4005 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0025 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0025 | 0.4005 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0043 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0025 | 0.4005 | 0.4005 |
Echinococcus granulosus | Transglutaminase | 0.0043 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0043 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0025 | 0.4005 | 0.4005 |
Mycobacterium tuberculosis | Long conserved protein | 0.0043 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0025 | 0.4005 | 0.4005 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0107 | 0.0107 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0043 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0043 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0025 | 0.4005 | 0.4005 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0043 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4005 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.