Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.3209 | 0.2241 |
Loa Loa (eye worm) | hypothetical protein | 0.0668 | 0.4787 | 0.4043 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0337 | 0.1578 | 0.3296 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0668 | 0.4787 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.004 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 0.3096 | 0.2112 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0494 | 0.3096 | 0.2112 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0494 | 0.3096 | 0.2112 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.3209 | 0.2241 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0668 | 0.4787 | 0.4043 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.3209 | 0.2241 |
Onchocerca volvulus | 0.0331 | 0.1519 | 0.5 | |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0668 | 0.4787 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0668 | 0.4787 | 0.4043 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0668 | 0.4787 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.3209 | 0.2241 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0668 | 0.4787 | 0.5 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0337 | 0.1578 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 0.3096 | 0.2112 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 0.3096 | 0.2112 |
Loa Loa (eye worm) | hypothetical protein | 0.0668 | 0.4787 | 0.4043 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0668 | 0.4787 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0337 | 0.1578 | 0.3296 |
Toxoplasma gondii | peptidase family M13 protein | 0.0668 | 0.4787 | 0.5 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0337 | 0.1578 | 0.3296 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0668 | 0.4787 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1519 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.3209 | 0.2241 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.3209 | 0.2241 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 0.3096 | 0.2112 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0337 | 0.1578 | 0.3296 |
Brugia malayi | Peptidase family M13 containing protein | 0.0668 | 0.4787 | 0.4043 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1206 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Inhibitory concentration was measured against growth hormone secretagogue receptor using cellular function assay with fluorescent calcium indicator; ND=not determined | ChEMBL. | 15780615 |
IC50 (binding) | > 10 uM | Inhibitory concentration was measured against growth hormone secretagogue receptor | ChEMBL. | 15780615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.