Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0167 | 0.0124 | 0.0124 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0227 | 0.0847 | 0.0847 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0227 | 0.0847 | 0.0847 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0227 | 0.0847 | 0.0847 |
Echinococcus multilocularis | carbonic anhydrase | 0.0496 | 0.4059 | 0.3984 |
Toxoplasma gondii | cathepsin CPL | 0.0227 | 0.0847 | 0.1378 |
Onchocerca volvulus | Cathepsin L homolog | 0.0227 | 0.0847 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0227 | 0.0847 | 0.0847 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0192 | 0.0421 | 0.0421 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0167 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.035 | 0.2317 | 0.2317 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0321 | 0.0321 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0183 | 0.0321 | 0.0199 |
Schistosoma mansoni | hypothetical protein | 0.0496 | 0.4059 | 0.4059 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0227 | 0.0847 | 0.0732 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0496 | 0.4059 | 0.4059 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0479 | 0.3853 | 0.3853 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0479 | 0.3853 | 0.3853 |
Entamoeba histolytica | cysteine protease, putative | 0.0227 | 0.0847 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0993 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0192 | 0.0421 | 0.03 |
Echinococcus multilocularis | cysteine protease | 0.0227 | 0.0847 | 0.0732 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0227 | 0.0847 | 0.0732 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0167 | 0.0124 | 0.0124 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0375 | 0.2614 | 0.2521 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0847 | 0.0847 |
Echinococcus granulosus | carbonic anhydrase II | 0.0993 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0496 | 0.4059 | 0.4059 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0479 | 0.3853 | 0.3853 |
Echinococcus multilocularis | glutamate receptor 2 | 0.035 | 0.2317 | 0.2221 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0184 | 0.0334 | 0.0334 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0496 | 0.4059 | 0.4059 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0192 | 0.0421 | 0.03 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0192 | 0.0421 | 0.03 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0993 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0993 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0227 | 0.0847 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0184 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | cathepsin B | 0.0184 | 0.0334 | 0.0334 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0993 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0167 | 0.0124 | 0.0124 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Echinococcus granulosus | cathepsin l1 | 0.0227 | 0.0847 | 0.0847 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0479 | 0.3853 | 0.3853 |
Plasmodium falciparum | carbonic anhydrase | 0.0496 | 0.4059 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0227 | 0.0847 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0192 | 0.0421 | 0.0421 |
Schistosoma mansoni | glutamate receptor kainate | 0.0167 | 0.0124 | 0.0124 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0993 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0192 | 0.0421 | 0.0421 |
Echinococcus granulosus | carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0277 | 0.1444 | 0.1444 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0993 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0227 | 0.0847 | 0.0847 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0227 | 0.0847 | 0.0847 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0496 | 0.4059 | 0.4059 |
Echinococcus multilocularis | cathepsin b | 0.0479 | 0.3853 | 0.3776 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0227 | 0.0847 | 0.0847 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0375 | 0.2614 | 0.2521 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus granulosus | glutamate receptor 1 | 0.0183 | 0.0321 | 0.0321 |
Brugia malayi | Glutamate receptor 2 precursor | 0.035 | 0.2317 | 0.2317 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0227 | 0.0847 | 0.0847 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0184 | 0.0334 | 0.394 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0479 | 0.3853 | 0.3776 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0479 | 0.3853 | 0.3853 |
Echinococcus granulosus | cathepsin b | 0.0479 | 0.3853 | 0.3853 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0313 | 0.1875 | 0.1773 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0227 | 0.0847 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.4059 | 0.4059 |
Schistosoma mansoni | carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0227 | 0.0847 | 0.0732 |
Echinococcus multilocularis | carbonic anhydrase | 0.0496 | 0.4059 | 0.3984 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Echinococcus granulosus | glutamate receptor 2 | 0.0313 | 0.1875 | 0.1875 |
Loa Loa (eye worm) | ctsf protein | 0.0227 | 0.0847 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.4059 | 0.4059 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0496 | 0.4059 | 0.4059 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0227 | 0.0847 | 0.0847 |
Echinococcus multilocularis | carbonic anhydrase | 0.0496 | 0.4059 | 0.3984 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0167 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.3853 | 0.3853 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0245 | 0.106 | 0.0947 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Leishmania major | cysteine peptidase A (CPA) | 0.0227 | 0.0847 | 0.0531 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0496 | 0.4059 | 0.4059 |
Brugia malayi | Glutamate receptor 1 precursor | 0.035 | 0.2317 | 0.2317 |
Giardia lamblia | Cathepsin B precursor | 0.0184 | 0.0334 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0167 | 0.0124 | 0.0124 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0227 | 0.0847 | 0.0847 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0993 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0227 | 0.0847 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0993 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0479 | 0.3853 | 0.3853 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Echinococcus granulosus | glutamate receptor 2 | 0.0375 | 0.2614 | 0.2614 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.4059 | 0.4059 |
Plasmodium vivax | vivapain-2 | 0.0227 | 0.0847 | 0.5 |
Echinococcus granulosus | glutamate receptor 4 | 0.0183 | 0.0321 | 0.0321 |
Toxoplasma gondii | hypothetical protein | 0.0496 | 0.4059 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0167 | 0.0124 | 0.0124 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0227 | 0.0847 | 0.0732 |
Leishmania major | carbonic anhydrase-like protein | 0.0993 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0227 | 0.0847 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0993 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0227 | 0.0847 | 0.0732 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0245 | 0.106 | 0.106 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Loa Loa (eye worm) | cysteine protease | 0.0227 | 0.0847 | 0.0847 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0496 | 0.4059 | 0.4059 |
Giardia lamblia | Cathepsin B precursor | 0.0184 | 0.0334 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.0167 | 0.0124 | 0.0124 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0479 | 0.3853 | 0.3853 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0321 | 0.0321 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0375 | 0.2614 | 0.2614 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0227 | 0.0847 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0227 | 0.0847 | 0.0847 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0227 | 0.0847 | 0.0847 |
Giardia lamblia | Cathepsin B precursor | 0.0184 | 0.0334 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0496 | 0.4059 | 0.4059 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log IC50 (functional) | = 5.8 | Inhibitory activity against MCP-1 induced Calcium flux in THP11-cells | ChEMBL. | 15729771 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.