Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.5979 | 0.8628 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0051 | 0.0712 | 0.1148 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0043 | 0.0473 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0043 | 0.0473 | 0.0473 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.015 | 0.3984 | 0.5 |
Brugia malayi | hypothetical protein | 0.0239 | 0.6924 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0106 | 0.2552 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0106 | 0.2552 | 0.3653 |
Echinococcus multilocularis | thymidylate synthase | 0.0106 | 0.2552 | 0.2525 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0649 | 0.089 |
Onchocerca volvulus | 0.0106 | 0.2552 | 0.3646 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.5979 | 0.8628 |
Mycobacterium ulcerans | thymidylate synthase | 0.0106 | 0.2552 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0043 | 0.0473 | 0.1735 |
Echinococcus granulosus | thymidylate synthase | 0.0106 | 0.2552 | 0.2552 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.015 | 0.3984 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.015 | 0.3984 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0239 | 0.6924 | 0.6913 |
Onchocerca volvulus | 0.0239 | 0.6938 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0106 | 0.2552 | 1 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0712 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0645 | 0.0884 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0649 | 0.2435 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.6924 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0043 | 0.0473 | 0.0634 |
Brugia malayi | dihydrofolate reductase family protein | 0.0043 | 0.0473 | 0.0634 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0043 | 0.0473 | 0.0634 |
Onchocerca volvulus | 0.0049 | 0.0645 | 0.0882 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.015 | 0.3984 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0239 | 0.6924 | 0.6924 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0649 | 0.2435 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.015 | 0.3984 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0106 | 0.2552 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.015 | 0.3984 | 1 |
Onchocerca volvulus | 0.0049 | 0.0649 | 0.0888 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.6938 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0332 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0106 | 0.2552 | 0.3653 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0645 | 0.242 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0043 | 0.0473 | 0.0438 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K obs / 1 (binding) | NA 0 M-1 s-1 | Inhibitory activity against human Leukocyte elastase; inactive (at 243-fold excess of inhibitor over enzyme) | ChEMBL. | 3643283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.