Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0337 | 0.0059 | 0.0059 |
Entamoeba histolytica | hypothetical protein | 0.033 | 0 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.1263 | 0.7389 | 0.7389 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.1593 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0337 | 0.0059 | 0.0059 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1263 | 0.7389 | 0.7389 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1263 | 0.7389 | 0.7389 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.1593 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Treponema pallidum | pfs protein (pfs) | 0.033 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1263 | 0.7389 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.1593 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Treponema pallidum | uridine phosphorylase (udp) | 0.033 | 0 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Brugia malayi | thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.033 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.033 | 0 | 0.5 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.1593 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0337 | 0.0059 | 0.008 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.1593 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0475 | 0.1148 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Chlamydia trachomatis | AMP nucleosidase | 0.033 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log MIC (functional) | = 4.109 ug ml-1 | Minimum inhibitory concentration of the compound was determined against Aspergillus niger | ChEMBL. | 15686890 |
-Log MIC (functional) | = 4.128 ug ml-1 | Minimum inhibitory concentration of the compound was determined against Candida albicans | ChEMBL. | 15686890 |
-Log MIC (functional) | = 4.201 ug ml-1 | Minimum inhibitory concentration of the compound was determined against Bacillus subtilis | ChEMBL. | 15686890 |
-Log MIC (functional) | = 4.304 ug ml-1 | Minimum inhibitory concentration of the compound was determined against Staphylococcus aureus | ChEMBL. | 15686890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.