Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | uridine phosphorylase (udp) | 0.033 | 0 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.1263 | 0.7389 | 0.7389 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0475 | 0.1148 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Chlamydia trachomatis | AMP nucleosidase | 0.033 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1263 | 0.7389 | 0.7389 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.1593 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.1593 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1263 | 0.7389 | 0.7389 |
Treponema pallidum | pfs protein (pfs) | 0.033 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | thymidylate synthase | 0.0337 | 0.0059 | 0.008 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1263 | 0.7389 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.1593 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0475 | 0.1148 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.1593 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0337 | 0.0059 | 0.0059 |
Entamoeba histolytica | hypothetical protein | 0.033 | 0 | 0.5 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.033 | 0 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.1593 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.033 | 0 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0337 | 0.0059 | 0.0059 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0337 | 0.0059 | 0.0059 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.033 | 0 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1593 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log MIC (functional) | = 4.109 ug ml-1 | Minimum inhibitory concentration of the compound was determined against Aspergillus niger | ChEMBL. | 15686890 |
-Log MIC (functional) | = 4.128 ug ml-1 | Minimum inhibitory concentration of the compound was determined against Candida albicans | ChEMBL. | 15686890 |
-Log MIC (functional) | = 4.201 ug ml-1 | Minimum inhibitory concentration of the compound was determined against Bacillus subtilis | ChEMBL. | 15686890 |
-Log MIC (functional) | = 4.304 ug ml-1 | Minimum inhibitory concentration of the compound was determined against Staphylococcus aureus | ChEMBL. | 15686890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.