Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1252 | 0.3513 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1252 | 0.3513 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1749 | 0.9089 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1094 | 0.1732 | 0.6554 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1252 | 0.3513 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1749 | 0.9089 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1252 | 0.3513 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.183 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.183 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1252 | 0.3513 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1749 | 0.9089 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1749 | 0.9089 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1175 | 0.2642 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1252 | 0.3513 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1252 | 0.3513 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1252 | 0.3513 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1252 | 0.3513 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.4 nM | Ki value against human carbonic anhydrase XII (hCA XII) | ChEMBL. | 15686894 |
Ki (binding) | = 3.4 nM | Ki value against human carbonic anhydrase XII (hCA XII) | ChEMBL. | 15686894 |
Ki (binding) | = 15 nM | Ki value against human carbonic anhydrase II (hCA II) | ChEMBL. | 15686894 |
Ki (binding) | = 15 nM | Ki value against human carbonic anhydrase II (hCA II) | ChEMBL. | 15686894 |
Ki (binding) | = 31 nM | Ki value against human carbonic anhydrase I (hCA I) | ChEMBL. | 15686894 |
Ki (binding) | = 31 nM | Ki value against human carbonic anhydrase I (hCA I) | ChEMBL. | 15686894 |
Ratio (binding) | 4.4 | Selectivity ratio against human carbonic anhydrases II and XII | ChEMBL. | 15686894 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.