Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phenylethanolamine N-methyltransferase | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 420 aa | 19.8 % | |
Echinococcus multilocularis | neuropeptides capa receptor | Adrenergic receptor alpha-2 | 450 aa | 486 aa | 20.6 % |
Brugia malayi | NNMT/PNMT/TEMT family protein | phenylethanolamine N-methyltransferase | 282 aa | 257 aa | 26.5 % |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 478 aa | 20.7 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Adrenergic receptor alpha-2 | 450 aa | 378 aa | 20.9 % |
Echinococcus multilocularis | serotonin receptor | Adrenergic receptor alpha-2 | 450 aa | 426 aa | 31.9 % |
Schistosoma mansoni | amine GPCR | Adrenergic receptor alpha-2 | 450 aa | 439 aa | 29.2 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 467 aa | 25.1 % | |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Adrenergic receptor alpha-2 | 450 aa | 473 aa | 24.1 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Adrenergic receptor alpha-2 | 450 aa | 423 aa | 31.7 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adrenergic receptor alpha-2 | 450 aa | 433 aa | 27.9 % |
Loa Loa (eye worm) | TYRA-2 protein | Adrenergic receptor alpha-2 | 450 aa | 488 aa | 23.8 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 476 aa | 21.0 % |
Echinococcus multilocularis | fmrfamide receptor | Adrenergic receptor alpha-2 | 450 aa | 366 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 1 | 1 |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0116 | 0.1497 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0116 | 0.1497 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0333 | 1 | 1 |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 1 | 1 |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Schistosoma mansoni | lipoxygenase | 0.0116 | 0.1497 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0078 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.0133 | 0.0891 |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 | |
Onchocerca volvulus | 0.0078 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.35 uM | Binding affinity against Human phenylethanolamine N-methyltransferase | ChEMBL. | 15686930 |
Ki (binding) | = 0.35 uM | Binding affinity against Human phenylethanolamine N-methyltransferase | ChEMBL. | 15686930 |
Ki (binding) | = 1.3 uM | Binding affinity against alpha 2 adrenergic receptor in rat cortex using [3H]-clonidine as radioliagnd | ChEMBL. | 15686930 |
Ki (binding) | = 1.3 uM | Binding affinity against alpha 2 adrenergic receptor in rat cortex using [3H]-clonidine as radioliagnd | ChEMBL. | 15686930 |
Selectivity (binding) | = 3.7 | Selectivity for inhibition of alpha 2 adrenergic receptor to that of phenylethanolamine N-methyltransferase | ChEMBL. | 15686930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.