Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 2, surface | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.1141 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0183 | 0.0729 | 0.0492 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0619 | 0.4951 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1141 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0274 | 0.1608 | 0.1608 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0229 | 0.1178 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.222 | 0.222 |
Onchocerca volvulus | 0.0183 | 0.0729 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0619 | 0.4951 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.0729 | 0.0492 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1141 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0274 | 0.1608 | 0.1393 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0619 | 0.4951 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1141 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0337 | 0.222 | 0.1609 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0337 | 0.222 | 0.1609 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0619 | 0.4951 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0619 | 0.4951 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0311 | 0.1971 | 0.1766 |
Brugia malayi | Dihydrofolate reductase | 0.1141 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1141 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0619 | 0.4951 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1141 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0229 | 0.1178 | 0.0484 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0229 | 0.1178 | 0.0952 |
Echinococcus granulosus | dihydrofolate reductase | 0.1141 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0183 | 0.0729 | 0.0729 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0248 | 0.1359 | 0.1138 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1141 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor; Not determined | ChEMBL. | 15686912 |
EC50 (functional) | = 11 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-3 adrenergic receptor | ChEMBL. | 15686912 |
EC50 (functional) | = 11 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-3 adrenergic receptor | ChEMBL. | 15686912 |
EC50 (functional) | = 16 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-2 adrenergic receptor | ChEMBL. | 15686912 |
EC50 (functional) | = 16 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-2 adrenergic receptor | ChEMBL. | 15686912 |
IA50 (functional) | = 28 % | Intrinsic activity against human beta-1 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 28 % | Intrinsic activity against human beta-1 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 43 % | Intrinsic activity against human beta-2 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 43 % | Intrinsic activity against human beta-2 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 87 % | Intrinsic activity against human beta-3 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 87 % | Intrinsic activity against human beta-3 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
Permeability (functional) | = 9 Papp* 10E6 cm/s | Permeability of compounds was determined in Caco-2 cell monolayer permeability assay; (high) | ChEMBL. | 15686912 |
Permeability (functional) | = 9 Papp* 10E6 cm/s | Permeability of compounds was determined in Caco-2 cell monolayer permeability assay; (high) | ChEMBL. | 15686912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.