Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 4 | 303 aa | 312 aa | 29.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0065 | 1 | 1 | |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0053 | 0.5421 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0053 | 0.5421 | 0.5 |
Onchocerca volvulus | 0.0065 | 1 | 1 | |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0053 | 0.5421 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0053 | 0.5421 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0053 | 0.5421 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5022 | 0.5022 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0053 | 0.5421 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0065 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0053 | 0.5421 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0053 | 0.5421 | 0.5421 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.5421 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0053 | 0.5421 | 0.5 |
Onchocerca volvulus | 0.0065 | 1 | 1 | |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0053 | 0.5421 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0053 | 0.5421 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.5421 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0053 | 0.5421 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0053 | 0.5421 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Onchocerca volvulus | 0.0065 | 1 | 1 | |
Onchocerca volvulus | 0.0065 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0065 | 1 | 1 |
Onchocerca volvulus | 0.0065 | 1 | 1 | |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0053 | 0.5421 | 0.5421 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.5421 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.5421 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0053 | 0.5421 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0053 | 0.5421 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0053 | 0.5421 | 0.5421 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0053 | 0.5421 | 0.5 |
Onchocerca volvulus | 0.0065 | 1 | 1 | |
Giardia lamblia | Kinase, CMGC CDK | 0.0053 | 0.5421 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0053 | 0.5421 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase | 0.0053 | 0.5421 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0053 | 0.5421 | 0.5 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0065 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0053 | 0.5421 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0053 | 0.5421 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0053 | 0.5421 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0053 | 0.5421 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.5421 | 0.5 |
Brugia malayi | cell division control protein 2 homolog | 0.0053 | 0.5421 | 0.5421 |
Onchocerca volvulus | 0.0065 | 1 | 1 | |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0053 | 0.5421 | 0.5421 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.3 uM | inhibitory concentration for anti-proliferative activity against A549 and H29 human tumor cell lines was determined | ChEMBL. | 15261277 |
IC50 (functional) | = 3.3 uM | inhibitory concentration for anti-proliferative activity against A549 and H29 human tumor cell lines was determined | ChEMBL. | 15261277 |
Ki (binding) | = 0.05 uM | Inhibition of Cyclin dependent kinase 2 | ChEMBL. | 15261277 |
Ki (binding) | = 0.05 uM | Inhibition of Cyclin dependent kinase 2 | ChEMBL. | 15261277 |
Ki (binding) | = 4.17 uM | Ihibition of Cyclin dependent kinase 4 | ChEMBL. | 15261277 |
Ki (binding) | = 4.17 uM | Ihibition of Cyclin dependent kinase 4 | ChEMBL. | 15261277 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15261277 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.