Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor IX | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | perforin-like protein 3 | 0.0055 | 0 | 0.5 |
Plasmodium vivax | perforin-like protein 1 | 0.0055 | 0 | 0.5 |
Plasmodium falciparum | perforin-like protein 2 | 0.0055 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0057 | 0.0223 | 0.5 |
Plasmodium falciparum | perforin-like protein 4 | 0.0055 | 0 | 0.5 |
Plasmodium falciparum | perforin-like protein 5 | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0078 | 0.2309 | 0.2309 |
Plasmodium vivax | perforin-like protein 2 | 0.0055 | 0 | 0.5 |
Toxoplasma gondii | MAC/Perforin domain-containing protein | 0.0055 | 0 | 0.5 |
Plasmodium vivax | perforin-like protein 3 | 0.0055 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0112 | 0.5574 | 1 |
Plasmodium vivax | perforin-like protein 5 | 0.0055 | 0 | 0.5 |
Plasmodium falciparum | perforin-like protein 1 | 0.0055 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0057 | 0.0223 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0158 | 1 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0057 | 0.0223 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0079 | 0.2382 | 0.2382 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.009 | 0.3415 | 0.3415 |
Echinococcus granulosus | nmda type glutamate receptor | 0.009 | 0.3415 | 0.3415 |
Plasmodium vivax | perforin-like protein 4 | 0.0055 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0057 | 0.0223 | 0.5 |
Toxoplasma gondii | perforin-like protein PLP1 | 0.0055 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0078 | 0.2309 | 0.2309 |
Chlamydia trachomatis | glutamine binding protein | 0.0057 | 0.0223 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0057 | 0.0223 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.12 nM | Binding affinity towards human factor Xa | ChEMBL. | 15454208 |
Ki (binding) | = 0.12 nM | Binding affinity towards human factor Xa | ChEMBL. | 15454208 |
Ki (binding) | = 11 nM | Binding affinity towards human factor IXa | ChEMBL. | 15454208 |
Ki (binding) | = 11 nM | Binding affinity towards human factor IXa | ChEMBL. | 15454208 |
Ratio (binding) | = 92 | Ratio of binding affinity towards human factor IXa to that of human factor Xa | ChEMBL. | 15454208 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.