Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0629 | 0.6855 | 0.6855 |
Loa Loa (eye worm) | lipase | 0.0883 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0629 | 0.6855 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0883 | 1 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0883 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0629 | 0.6855 | 0.6855 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0076 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0076 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0883 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0883 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0076 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0155 | 0.0983 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0629 | 0.6855 | 0.6855 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0155 | 0.0983 | 1 |
Onchocerca volvulus | 0.0883 | 1 | 0.5 | |
Schistosoma mansoni | amidase | 0.0629 | 0.6855 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0883 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0629 | 0.6855 | 0.6855 |
Brugia malayi | amidase | 0.0629 | 0.6855 | 0.6855 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0076 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0883 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0883 | 1 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0076 | 0 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0076 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0883 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0076 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0883 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0629 | 0.6855 | 0.6855 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 uM | Inhibitory activity towards acetylcholine esterase (AChE) | ChEMBL. | 15369385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.