Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 1 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 2, surface | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA helicase recq5 | 0.0019 | 0.2517 | 0.4147 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0096 | 0.5 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.2517 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.1509 | 0.1427 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0019 | 0.2517 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.607 | 0.5371 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0019 | 0.2517 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0096 | 0.0381 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.2517 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0019 | 0.2517 | 0.5 |
Schistosoma mansoni | DNA helicase recq1 | 0.0019 | 0.2517 | 0.4147 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.1509 | 0.2486 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0019 | 0.2517 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0096 | 0.0158 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0019 | 0.2517 | 0.2445 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1509 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 1 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.2517 | 0.5 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.2517 | 0.1187 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.2517 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0019 | 0.2517 | 0.2445 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0019 | 0.2517 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 1 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0019 | 0.2517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.607 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0096 | 0.0000000020559 |
Echinococcus granulosus | bloom syndrome protein | 0.0019 | 0.2517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.1509 | 0.2486 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.1509 | 0.2486 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0019 | 0.2517 | 0.1187 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0019 | 0.2517 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2517 | 0.2445 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.2517 | 0.1187 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0096 | 0.0381 |
Echinococcus multilocularis | bloom syndrome protein | 0.0019 | 0.2517 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0019 | 0.2517 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.2517 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0019 | 0.2517 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.607 | 0.6032 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.2517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.1509 | 0.2486 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0019 | 0.2517 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.59 nM | Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-3 adrenergic receptor | ChEMBL. | 15546707 |
EC50 (functional) | = 0.59 nM | Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-3 adrenergic receptor | ChEMBL. | 15546707 |
EC50 (binding) | = 0.59 nM | Agonist activity at Homo sapiens (human) beta3 adrenoreceptor | ChEMBL. | 21170122 |
EC50 (functional) | = 7.3 nM | Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-2 adrenergic receptor | ChEMBL. | 15546707 |
EC50 (functional) | = 7.3 nM | Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-2 adrenergic receptor | ChEMBL. | 15546707 |
EC50 (binding) | = 7.3 nM | Agonist activity at Homo sapiens (human) beta1 adrenoreceptor | ChEMBL. | 21170122 |
EC50 (functional) | = 26 nM | Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor | ChEMBL. | 15546707 |
EC50 (functional) | = 26 nM | Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor | ChEMBL. | 15546707 |
EC50 (functional) | = 26 nM | Agonist activity at Homo sapiens (human) beta2 adrenoreceptor | ChEMBL. | 21170122 |
IA (functional) | = 48 % | Intrinsic activity expressed as percentage of maximal stimulation with isoproterenol of Beta-1 adrenergic receptor | ChEMBL. | 15546707 |
IA (functional) | = 48 % | Intrinsic activity expressed as percentage of maximal stimulation with isoproterenol of Beta-1 adrenergic receptor | ChEMBL. | 15546707 |
IA (functional) | = 77 % | Intrinsic activity expressed as percentage of maximal stimulation with isoproterenol of Beta-2 adrenergic receptor | ChEMBL. | 15546707 |
IA (functional) | = 77 % | Intrinsic activity expressed as percentage of maximal stimulation with isoproterenol of Beta-2 adrenergic receptor | ChEMBL. | 15546707 |
IA (functional) | = 86 % | Intrinsic activity expressed as percentage of maximal stimulation with isoproterenol of Beta-3 adrenergic receptor | ChEMBL. | 15546707 |
IA (functional) | = 86 % | Intrinsic activity expressed as percentage of maximal stimulation with isoproterenol of Beta-3 adrenergic receptor | ChEMBL. | 15546707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.