Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0053 | 0.0718 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0287 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.0718 | 0.0718 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0287 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0287 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0287 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0053 | 0.0718 | 0.0718 |
Echinococcus multilocularis | cysteine protease | 0.0053 | 0.0718 | 0.0718 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0053 | 0.0718 | 0.0718 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.0718 | 0.2662 |
Echinococcus multilocularis | cathepsin b | 0.0287 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0053 | 0.0718 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.0718 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.0718 | 0.2662 |
Onchocerca volvulus | 0.0053 | 0.0718 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0053 | 0.0718 | 0.0718 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0718 | 0.0718 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0053 | 0.0718 | 1 |
Onchocerca volvulus | 0.0053 | 0.0718 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0053 | 0.0718 | 0.0718 |
Giardia lamblia | Cathepsin B precursor | 0.0103 | 0.2699 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0103 | 0.2699 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0053 | 0.0718 | 0.0718 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.0718 | 0.2662 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.0718 | 0.2662 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.0718 | 0.0718 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0053 | 0.0718 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0053 | 0.0718 | 0.0718 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0103 | 0.2699 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Onchocerca volvulus | Cathepsin L homolog | 0.0053 | 0.0718 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.0718 | 0.0718 |
Onchocerca volvulus | 0.0053 | 0.0718 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.0718 | 0.0718 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0053 | 0.0718 | 0.0718 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0287 | 1 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0103 | 0.2699 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Plasmodium vivax | vivapain-2 | 0.0053 | 0.0718 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0103 | 0.2699 | 0.2699 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0053 | 0.0718 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0053 | 0.0718 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0053 | 0.0718 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0053 | 0.0718 | 0.0718 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.0718 | 0.0718 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Onchocerca volvulus | 0.0053 | 0.0718 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Toxoplasma gondii | cathepsin B | 0.0103 | 0.2699 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0053 | 0.0718 | 0.0718 |
Echinococcus granulosus | cathepsin b | 0.0287 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0287 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0053 | 0.0718 | 0.0718 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Loa Loa (eye worm) | cathepsin B | 0.0103 | 0.2699 | 0.2699 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Entamoeba histolytica | cysteine protease, putative | 0.0053 | 0.0718 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0053 | 0.0718 | 0.0718 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0053 | 0.0718 | 0.0718 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.0718 | 0.0718 |
Giardia lamblia | Cathepsin B precursor | 0.0103 | 0.2699 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.0718 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0041 | 0.0239 | 0.0239 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Onchocerca volvulus | 0.0053 | 0.0718 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0053 | 0.0718 | 0.0718 |
Leishmania major | cysteine peptidase A (CPA) | 0.0053 | 0.0718 | 0.2662 |
Loa Loa (eye worm) | cysteine protease | 0.0053 | 0.0718 | 0.0718 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0053 | 0.0718 | 0.0718 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.0718 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.0718 | 0.0718 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0053 | 0.0718 | 0.0718 |
Brugia malayi | cathepsin L-like precursor | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Loa Loa (eye worm) | fibroinase | 0.0053 | 0.0718 | 0.0718 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Plasmodium vivax | vivapain-2 | 0.0053 | 0.0718 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0103 | 0.2699 | 0.2699 |
Onchocerca volvulus | Cathepsin F homolog | 0.0053 | 0.0718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0718 | 0.0718 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0718 | 0.0718 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.0718 | 0.2662 |
Echinococcus granulosus | cathepsin l1 | 0.0053 | 0.0718 | 0.0718 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.0718 | 0.2662 |
Onchocerca volvulus | 0.0053 | 0.0718 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0103 | 0.2699 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.0718 | 0.0718 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | NI 0 % | Ability of the conjugate to block HIV-1 production when supplemented in a culture medium; NI= No inhibition of the HIV-1 replication even at concentration >5 uM | ChEMBL. | 15369382 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.