Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0493 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0045 | 0.0698 | 0.0698 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0045 | 0.0693 | 0.2855 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.2944 | 0.6648 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0045 | 0.0698 | 0.2874 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0045 | 0.0693 | 0.0693 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0164 | 0.3032 | 0.3032 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0045 | 0.0693 | 0.0693 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0693 | 0.1565 |
Brugia malayi | Uncoordinated protein 44 | 0.0045 | 0.0693 | 0.1565 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0045 | 0.0693 | 0.1565 |
Onchocerca volvulus | 0.0129 | 0.234 | 0.5284 | |
Schistosoma mansoni | jun-related protein | 0.0134 | 0.2428 | 1 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0045 | 0.0693 | 0.0693 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0493 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0164 | 0.3032 | 0.3032 |
Onchocerca volvulus | 0.0235 | 0.4428 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.4428 | 1 |
Echinococcus granulosus | jun protein | 0.0164 | 0.3032 | 0.3032 |
Echinococcus multilocularis | jun protein | 0.0164 | 0.3032 | 0.3032 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.0705 | 0.1592 |
Brugia malayi | hypothetical protein | 0.0129 | 0.234 | 0.5284 |
Schistosoma mansoni | netrin receptor unc5 | 0.0045 | 0.0693 | 0.2855 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0493 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0698 | 0.1576 |
Brugia malayi | bZIP transcription factor family protein | 0.0164 | 0.3032 | 0.6848 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0493 | 0.2031 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0045 | 0.0693 | 0.1565 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0493 | 0.0493 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.2428 | 1 |
Echinococcus granulosus | death domain containing protein | 0.0045 | 0.0693 | 0.0693 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0519 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0493 | 0.5 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0045 | 0.0693 | 0.0693 |
Echinococcus granulosus | Ankyrin | 0.0045 | 0.0698 | 0.0698 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0493 | 0.1114 |
Onchocerca volvulus | Netrin receptor homolog | 0.0045 | 0.0693 | 0.1565 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0693 | 0.2855 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0493 | 0.2031 |
Brugia malayi | Death domain containing protein | 0.0045 | 0.0693 | 0.1565 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0493 | 0.0493 |
Brugia malayi | hypothetical protein | 0.0235 | 0.4428 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity against Escherichia coli strain 25922 | ChEMBL. | 15341485 |
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity against Escherichia coli strain 25922 | ChEMBL. | 15341485 |
MIC (functional) | = 0.2 ug ml-1 | Antibacterial activity against Staphylococcus aureus strain St au 29213 | ChEMBL. | 15341485 |
MIC (functional) | = 0.2 ug ml-1 | Antibacterial activity against Staphylococcus aureus strain St au 33591 MRSA | ChEMBL. | 15341485 |
MIC (functional) | = 1.56 ug ml-1 | Antibacterial activity against Enterococcus faecalis strain 29212 | ChEMBL. | 15341485 |
MIC (functional) | = 6.25 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa strain 27853 | ChEMBL. | 15341485 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.