Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Leishmania mexicana | oligopeptidase b,serine peptidase, clan SC, family S9A-like protein | Prolyl endopeptidase | 710 aa | 720 aa | 24.7 % |
Trypanosoma brucei | oligopeptidase b | Prolyl endopeptidase | 710 aa | 630 aa | 26.3 % |
Onchocerca volvulus | Prolyl endopeptidase | 710 aa | 722 aa | 47.6 % | |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | Prolyl endopeptidase | 710 aa | 741 aa | 25.6 % |
Leishmania infantum | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Leishmania major | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.9 % |
Trypanosoma brucei gambiense | oligopeptidase B, putative | Prolyl endopeptidase | 710 aa | 629 aa | 26.4 % |
Trypanosoma congolense | oligopeptidase b | Prolyl endopeptidase | 710 aa | 589 aa | 27.8 % |
Leishmania donovani | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | Prolyl endopeptidase | 710 aa | 714 aa | 26.5 % |
Leishmania braziliensis | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 608 aa | 26.0 % |
Dictyostelium discoideum | oligopeptidase B | Prolyl endopeptidase | 710 aa | 735 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0304 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0163 | 0.3299 | 0.32 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0158 | 0.3055 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0304 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0163 | 0.3299 | 0.32 |
Trypanosoma brucei | prolyl endopeptidase | 0.0158 | 0.3055 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0158 | 0.3055 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0158 | 0.3055 | 0.3055 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0163 | 0.3299 | 0.3299 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.3217 | 0.3117 |
Echinococcus granulosus | prolyl endopeptidase | 0.0158 | 0.3055 | 0.2953 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0158 | 0.3055 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0097 | 0.0145 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.3055 | 0.2953 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.3055 | 0.2953 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.3217 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0163 | 0.3299 | 0.32 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0097 | 0.0145 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0163 | 0.3299 | 0.32 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.3055 | 0.2953 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0158 | 0.3055 | 0.2953 |
Toxoplasma gondii | prolyl endopeptidase | 0.0158 | 0.3055 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.2264 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0304 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0304 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.3217 | 0.3117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19000 nM | In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 degree C for 60 min | ChEMBL. | 16033257 |
IC50 (binding) | = 19000 nM | In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 degree C for 60 min | ChEMBL. | 16033257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.