Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen-related receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Steroid receptor seven-up type 2 | estrogen-related receptor alpha | 423 aa | 358 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0039 | 0.0255 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.6401 | 0.6401 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0028 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | FXNA | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0279 | 0.6146 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0039 | 0.0255 | 1 |
Brugia malayi | Peptidase family M28 containing protein | 0.0028 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 0.905 | 0.905 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0028 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0028 | 0 | 0.5 |
Brugia malayi | nicalin | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0425 | 0.9745 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.2 uM | Inhibition of estrogen-related receptor alpha Gal4 activity | ChEMBL. | 15509154 |
IC50 (binding) | = 2.2 uM | Inhibition of estrogen-related receptor alpha Gal4 activity | ChEMBL. | 15509154 |
Inhibition (binding) | = 57 % | Percent inhibition of estrogen-related receptor alpha Gal4 activity at 10 uM | ChEMBL. | 15509154 |
Inhibition (binding) | = 57 % | Percent inhibition of estrogen-related receptor alpha Gal4 activity at 10 uM | ChEMBL. | 15509154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.