TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 244.253 | Formula: C11H12N6O
H donors: 1 H acceptors: 4 LogP: 0.25 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CCn1c(nc2c1ccnc2C)c1nonc1N
InChi: 1S/C11H12N6O/c1-3-17-7-4-5-13-6(2)8(7)14-11(17)9-10(12)16-18-15-9/h4-5H,3H2,1-2H3,(H2,12,16)
InChiKey: XXKDLQRQZKRLLN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ribosomal protein S6 kinase, 90kDa, polypeptide 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	serine/threonine-protein kinase, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Babesia bovis	cAMP-dependent protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	serine/threonine-protein kinase ypk, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	cAMP-dependent protein kinase catalytic subunit, putative	Get druggable targets OG5_128437	All targets in OG5_128437
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128437	All targets in OG5_128437

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cathepsin F-like cysteine proteinase	0.0072	0.0309	0.0306
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0259	0.2217	0.2214
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.0309	0.0936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0183	0.1444	0.4367
Schistosoma mansoni	cathepsin F (C01 family)	0.0183	0.1444	0.1171
Brugia malayi	Papain family cysteine protease containing protein	0.0259	0.2217	0.2214
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0259	0.2217	0.1969
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0183	0.1444	0.4367
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Giardia lamblia	Cathepsin B precursor	0.0366	0.3306	1
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0076	0.0351	0.0348
Entamoeba histolytica	cysteine proteinase, putative	0.0183	0.1444	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.0309	0.0936
Plasmodium vivax	vivapain-3	0.0148	0.1083	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0072	0.0309	0.0306
Echinococcus multilocularis	cathepsin L cysteine protease	0.0259	0.2217	0.1969
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Brugia malayi	Cathepsin L-like precursor	0.0259	0.2217	0.2214
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0072	0.0309	0.0936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.0309	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0351	0.0348
Trypanosoma cruzi	cysteine peptidase, putative	0.0259	0.2217	0.1969
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0366	0.3306	0.3093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.0309	0.0936
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1022	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0148	0.1083	0.0798
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0259	0.2217	0.1969
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0259	0.2217	0.1969
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0004	0.0011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0309	0.0306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Trypanosoma cruzi	cysteine peptidase, putative	0.0259	0.2217	0.1969
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0259	0.2217	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0072	0.0309	0.0936
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0259	0.2217	0.6706
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0259	0.2217	0.1969
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1444	0.1441
Onchocerca volvulus		0.0259	0.2217	1
Entamoeba histolytica	cysteine proteinase 2	0.0148	0.1083	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0259	0.2217	0.1969
Toxoplasma gondii	cathepsin B	0.0366	0.3306	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0183	0.1444	0.1171
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Trypanosoma cruzi	cysteine peptidase, putative	0.0148	0.1083	0.0798
Echinococcus granulosus	cathepsin L cysteine protease	0.0148	0.1083	0.0798
Loa Loa (eye worm)	cathepsin B	0.0366	0.3306	0.3304
Plasmodium vivax	vivapain-1	0.0148	0.1083	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0259	0.2217	0.6706
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0148	0.1083	0.3275
Plasmodium vivax	unspecified product	0.0076	0.0351	0.022
Echinococcus multilocularis	cathepsin b	0.1022	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1022	1	1
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Echinococcus granulosus	cathepsin b	0.1022	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0309	0.0936
Plasmodium vivax	vivapain-2	0.0259	0.2217	1
Brugia malayi	Papain family cysteine protease containing protein	0.0072	0.0309	0.0306
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0072	0.0309	0.0936
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Loa Loa (eye worm)	fibroinase	0.0259	0.2217	0.2214
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0259	0.2217	0.6706
Entamoeba histolytica	cysteine proteinase, putative	0.0259	0.2217	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0259	0.2217	0.6706
Onchocerca volvulus		0.0183	0.1444	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.0309	0.0936
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1022	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0259	0.2217	0.6706
Brugia malayi	Papain family cysteine protease containing protein	0.0148	0.1083	0.1079
Echinococcus granulosus	cathepsin L	0.0148	0.1083	0.0798
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0148	0.1083	0.0798
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0072	0.0309	0.0936
Echinococcus granulosus	cathepsin b	0.1022	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Onchocerca volvulus		0.0259	0.2217	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0072	0.0309	0.0936
Giardia lamblia	Cathepsin B precursor	0.0366	0.3306	1
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0004	0.0011
Entamoeba histolytica	cysteine proteinase, putative	0.0148	0.1083	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0072	0.0309	0.0306
Onchocerca volvulus	Cathepsin F homolog	0.0259	0.2217	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0259	0.2217	0.2214
Entamoeba histolytica	cysteine proteinase, putative	0.0148	0.1083	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1444	0.1441
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0072	0.0309	0.0936
Onchocerca volvulus		0.0259	0.2217	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0183	0.1444	0.1441
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0072	0.0309	0.0936
Brugia malayi	Cathepsin L-like precursor	0.0076	0.0351	0.0348
Onchocerca volvulus		0.0259	0.2217	1
Brugia malayi	Cathepsin L-like precursor	0.0259	0.2217	0.2214
Echinococcus multilocularis	cysteine protease	0.0259	0.2217	0.1969
Onchocerca volvulus		0.0259	0.2217	1
Schistosoma mansoni	cathepsin s	0.0076	0.0351	0.0043
Brugia malayi	Cathepsin L-like precursor	0.0259	0.2217	0.2214
Echinococcus multilocularis	cathepsin L cysteine protease	0.0259	0.2217	0.1969
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Loa Loa (eye worm)	hypothetical protein	0.0259	0.2217	0.2214
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0004	0.0011
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0072	0.0309	0.0306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0259	0.2217	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0148	0.1083	0.0798
Brugia malayi	cathepsin L precursor	0.0072	0.0309	0.0306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.0309	0.0936
Echinococcus granulosus	cathepsin l1	0.0259	0.2217	0.1969
Onchocerca volvulus		0.0259	0.2217	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0259	0.2217	0.6706
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0148	0.1083	0.0798
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0259	0.2217	0.6706
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.0309	0.0936
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0309	0.0936
Echinococcus multilocularis	cathepsin L	0.0148	0.1083	0.0798
Trypanosoma cruzi	cysteine proteinase, putative	0.0148	0.1083	0.0798
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Entamoeba histolytica	cysteine proteinase, putative	0.0259	0.2217	1
Brugia malayi	Cathepsin L-like precursor	0.0259	0.2217	0.2214
Brugia malayi	Cathepsin L-like precursor	0.0183	0.1444	0.1441
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0259	0.2217	0.6706
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Loa Loa (eye worm)	cysteine protease	0.0259	0.2217	0.2214
Onchocerca volvulus	Cathepsin L homolog	0.0259	0.2217	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0259	0.2217	0.1969
Giardia lamblia	Cathepsin B precursor	0.0366	0.3306	1
Entamoeba histolytica	cysteine protease, putative	0.0259	0.2217	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0072	0.0309	0.0306
Brugia malayi	Papain family cysteine protease containing protein	0.0148	0.1083	0.1079
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0309	0.0306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0072	0.0309	0.0936
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0259	0.2217	0.6706
Echinococcus granulosus	cathepsin l1	0.0183	0.1444	0.1171
Loa Loa (eye worm)	ctsf protein	0.0259	0.2217	0.2214
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0148	0.1083	0.4054
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0366	0.3306	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0072	0.0309	0.0936
Onchocerca volvulus		0.0259	0.2217	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0259	0.2217	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0309	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0351	0.0348
Brugia malayi	cathepsin F-like cysteine proteinase	0.0076	0.0351	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0309	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0351	0.0348
Entamoeba histolytica	cysteine proteinase 1, putative	0.0148	0.1083	0.4054
Loa Loa (eye worm)	hypothetical protein	0.1022	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1022	1	1
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Brugia malayi	cathepsin L-like precursor	0.0183	0.1444	0.1441
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0366	0.3306	0.3093
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.0351	0.0043
Echinococcus granulosus	cysteine protease	0.0148	0.1083	0.0798
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Entamoeba histolytica	cysteine proteinase, putative	0.0148	0.1083	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0259	0.2217	0.1969
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0259	0.2217	0.1969
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0259	0.2217	0.6706
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1444	0.1441
Brugia malayi	cathepsin L-like cysteine proteinase	0.0072	0.0309	0.0306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0148	0.1083	0.3275
Brugia malayi	fibroinase precursor	0.0072	0.0309	0.0306
Brugia malayi	Papain family cysteine protease containing protein	0.0072	0.0309	0.0306
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0366	0.3306	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Echinococcus multilocularis	cathepsin b	0.1022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0309	0.0306
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0072	0.0309	0.0306
Brugia malayi	Cathepsin L-like precursor	0.0259	0.2217	0.2214
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1022	1	1
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Toxoplasma gondii	cathepsin CPL	0.0259	0.2217	0.6366
Trypanosoma cruzi	cysteine peptidase, putative	0.0259	0.2217	0.1969
Brugia malayi	Cathepsin L-like precursor	0.0259	0.2217	0.2214
Brugia malayi	Cathepsin L-like precursor	0.0183	0.1444	0.1441
Onchocerca volvulus	Cathepsin L homolog	0.0259	0.2217	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0309	0.0306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Trypanosoma cruzi	cruzipain precursor, putative	0.0076	0.0351	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0259	0.2217	0.6706
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0076	0.0351	0.0348
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0072	0.0309	0.0306
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0072	0.0309	0.0936
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0259	0.2217	0.6706
Trypanosoma cruzi	cysteine proteinase, putative	0.0148	0.1083	0.0798
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0259	0.2217	0.5102
Echinococcus multilocularis	cysteine protease	0.0259	0.2217	0.1969
Trypanosoma cruzi	cysteine protease, putative	0.0148	0.1083	0.0798
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0366	0.3306	1
Plasmodium vivax	unspecified product	0.0148	0.1083	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0148	0.1083	0.4054
Plasmodium vivax	vivapain-2	0.0259	0.2217	1
Entamoeba histolytica	cysteine protease, putative	0.0148	0.1083	0.4054
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0072	0.0309	0.0306

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8 nM	Inhibitory concentration against MSK-1	ChEMBL.	15955699
IC50 (binding)	= 8 nM	Inhibitory concentration against MSK-1	ChEMBL.	15955699
Inhibition (binding)	= 21	Ratio of RSK-1 IC50 to MSK-1 IC50	ChEMBL.	15955699
Ratio (binding)	= 104	Ratio of GSK-3 IC50 to MSK-1 IC50	ChEMBL.	15955699

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL364413

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 330069