Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma congolense | oligopeptidase b | Prolyl endopeptidase | 710 aa | 589 aa | 27.8 % |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | Prolyl endopeptidase | 710 aa | 714 aa | 26.5 % |
Leishmania donovani | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Leishmania major | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.9 % |
Trypanosoma brucei gambiense | oligopeptidase B, putative | Prolyl endopeptidase | 710 aa | 629 aa | 26.4 % |
Leishmania infantum | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Leishmania braziliensis | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 608 aa | 26.0 % |
Dictyostelium discoideum | oligopeptidase B | Prolyl endopeptidase | 710 aa | 735 aa | 23.7 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Leishmania mexicana | oligopeptidase b,serine peptidase, clan SC, family S9A-like protein | Prolyl endopeptidase | 710 aa | 720 aa | 24.7 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Onchocerca volvulus | Prolyl endopeptidase | 710 aa | 722 aa | 47.6 % | |
Trypanosoma brucei | oligopeptidase b | Prolyl endopeptidase | 710 aa | 630 aa | 26.3 % |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | Prolyl endopeptidase | 710 aa | 741 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0078 | 0.0894 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.562 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0158 | 0.562 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0089 | 0.1521 | 0.2706 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0078 | 0.0894 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0158 | 0.562 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0158 | 0.562 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0232 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0089 | 0.1521 | 0.2706 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0089 | 0.1521 | 0.2706 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.562 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0158 | 0.562 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0158 | 0.562 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.562 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0158 | 0.562 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0232 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0232 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0232 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0232 | 1 | 1 |
Plasmodium falciparum | peptide deformylase | 0.0232 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0089 | 0.1521 | 0.2706 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0232 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0089 | 0.1521 | 0.2706 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0078 | 0.0894 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0089 | 0.1521 | 0.2706 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.0894 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0078 | 0.0894 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0078 | 0.0894 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0232 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0158 | 0.562 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0089 | 0.1521 | 0.2706 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.4642 | 0.4642 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0078 | 0.0894 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 48 nM | In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 degree C for 60 min | ChEMBL. | 16033257 |
IC50 (binding) | = 48 nM | In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 degree C for 60 min | ChEMBL. | 16033257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.