Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). | 0.1689 | 0.4863 | 1 |
Mycobacterium ulcerans | chorismate synthase | 0.3426 | 1 | 1 |
Echinococcus granulosus | cdgsh iron sulfur domain containing protein | 0.0237 | 0.0567 | 1 |
Plasmodium falciparum | chorismate synthase | 0.3426 | 1 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0591 | 0.1614 | 0.1404 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0365 | 0.5992 |
Toxoplasma gondii | chorismate synthase, putative | 0.3426 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 0.0163 | 0.5 | |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.033 | 0.0841 | 0.0611 |
Schistosoma mansoni | CDGSH-type Zn finger-containing protein-like protein | 0.0251 | 0.0609 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.055 | 0.1491 | 0.2699 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0062 | 0.103 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.033 | 0.0841 | 0.1291 |
Echinococcus multilocularis | cdgsh iron sulfur domain containing protein | 0.0237 | 0.0567 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0201 | 0.0461 | 0.5 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.1689 | 0.4863 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0201 | 0.0461 | 0.0222 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0128 | 0.0245 | 0.4021 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0314 | 0.0795 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 0.0365 | 0.6439 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.033 | 0.0841 | 0.0611 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0115 | 0.0204 | 0.3351 |
Echinococcus granulosus | geminin | 0.0169 | 0.0365 | 0.6439 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.0598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0259 | 0.4328 |
Plasmodium vivax | chorismate synthase | 0.3426 | 1 | 0.5 |
Brugia malayi | Uncharacterized hematopoietic stem/progenitor cells protein MDS029 | 0.0101 | 0.0163 | 0.2056 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0591 | 0.1614 | 0.1404 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0201 | 0.0461 | 0.5 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0201 | 0.0461 | 0.0222 |
Schistosoma mansoni | hypothetical protein | 0.0251 | 0.0609 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0365 | 0.5992 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0163 | 0.2734 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 9 % | Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M | ChEMBL. | 15974585 |
Inhibition (functional) | = 9 % | Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M | ChEMBL. | 15974585 |
Inhibition (functional) | = 30 % | Inhibition of interleukin-8 induced chemotaxis of human polymorphonuclear cells at 100 nM | ChEMBL. | 15974585 |
Inhibition (functional) | = 30 % | Inhibition of interleukin-8 induced chemotaxis of human polymorphonuclear cells at 100 nM | ChEMBL. | 15974585 |
Inhibition (functional) | = 63 % | Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M | ChEMBL. | 15974585 |
Inhibition (functional) | = 63 % | Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M | ChEMBL. | 15974585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.