Detailed view for LOAG_00684

Basic information

TDR Targets ID: 936860
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 9.4464 | Length (AA): 107 | MW (Da): 12170 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09360   Iron-binding zinc finger CDGSH type

Gene Ontology

Mouse over links to read term descriptions.
GO:0051537   2 iron, 2 sulfur cluster binding  
GO:0043231   intracellular membrane-bounded organelle  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 62 3eo9 (H) 18 82 34.00 0.56 0.21 0.643339 1.82
41 105 4ooa (A) 68 133 51.00 0 1 1.22218 -0.37
65 107 6avj (A) 54 92 38.00 0.00022 0.61 0.779569 -0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130323)

Species Accession Gene Product
Arabidopsis thaliana AT5G51720   CDGSH iron-sulfur domain-containing protein NEET
Brugia malayi Bm1_01440   Uncharacterized hematopoietic stem/progenitor cells protein MDS029
Caenorhabditis elegans CELE_W02B12.15   Protein W02B12.15, isoform A
Drosophila melanogaster Dmel_CG1458   CG1458 gene product from transcript CG1458-RA
Echinococcus granulosus EgrG_001148300   cdgsh iron sulfur domain containing protein
Echinococcus multilocularis EmuJ_001148300   cdgsh iron sulfur domain containing protein
Homo sapiens 493856   CDGSH iron sulfur domain 2
Homo sapiens ENSG00000122873   CDGSH iron sulfur domain 1
Loa Loa (eye worm) LOAG_00684   hypothetical protein
Mus musculus 667631   predicted gene 8738
Mus musculus ENSMUSG00000037710   CDGSH iron sulfur domain 1
Mus musculus ENSMUSG00000028165   CDGSH iron sulfur domain 2
Oryza sativa 4343177   Os07g0467200
Onchocerca volvulus OVOC10863  
Schistosoma japonicum Sjp_0074810   CDGSH iron sulfur domain-containing protein 2 homolog, putative
Schistosoma mansoni Smp_082570   CDGSH-type Zn finger-containing protein-like protein
Schistosoma mansoni Smp_120170   hypothetical protein
Schmidtea mediterranea mk4.032988.00  
Schmidtea mediterranea mk4.007571.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens CDGSH iron sulfur domain 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0211 0.2613 0.7719
0.02 0.2782 0.337
0.0307 0.3179 0.5743
0.0099 0.3183 0.3153
0.0229 0.2798 0.3525
0.0212 0.3722 0.6522
0.0198 0.2685 0.7719
0.0537 0.2681 0.3362
0.0107 0.3343 1
0.0102 0.2906 0.3848
0.0309 0.3847 1
0.021 0.3003 0.3662
0.0113 0.3878 1
0.0421 0.2597 0.2707
0.0213 0.2613 0.7719
0.023 0.2614 0.7719
0.031 0.3805 0.3805
0.0212 0.3808 1
0.0425 0.3892 0.8115
0.0305 0.2984 1
0.0234 0.3308 0.7767
0.01 0.3801 1
0.0408 0.3935 1
0.023 0.2672 0.7719
0.0527 0.3496 0.3659
0.0525 0.3327 0.3494
0.0206 0.2657 0.7706
0.0421 0.2557 0.884
0.0208 0.2631 0.7719
0.0197 0.2542 0.2542
0.0225 0.3316 0.7772
0.0079 0.3645 0.3645
0.0102 0.3135 0.31
0.0409 0.2552 0.2693
0.0208 0.2586 1
0.0098 0.3638 1
0.0205 0.2672 0.7719
0.0104 0.3645 0.4785
0.0235 0.265 0.3753
0.0197 0.2542 0.2542
0.0212 0.3016 0.6587
0.0099 0.3851 0.6643
0.0245 0.2924 0.7786
0.0122 0.3143 0.8659
0.0442 0.2741 0.2865
0.0122 0.3284 0.3284
0.0245 0.2685 0.7719
0.0442 0.2745 0.2913
0.0235 0.3649 1
0.0199 0.3708 1
0.0409 0.2559 0.2747
0.0079 0.3645 0.3645
0.0419 0.2814 0.442
0.0227 0.2614 0.7719
0.0318 0.2989 1
0.0245 0.2824 0.9361
0.02 0.3222 0.3962
0.0197 0.2542 0.2542
0.0122 0.3284 0.3284
0.0201 0.2606 0.7294
0.0332 0.3293 0.9751
0.0198 0.2685 0.7351
0.0107 0.3649 0.6408
0.0102 0.2766 0.2766
0.0318 0.253 0.7138
0.0332 0.3842 1
0.0197 0.2685 0.7719
0.0535 0.2639 0.3727
0.0212 0.3943 0.4334
0.02 0.2652 0.7702
0.01 0.3807 1
0.0315 0.3847 1
0.0232 0.2603 0.7712
0.0098 0.2851 0.3588
0.0425 0.3892 0.8115
0.0225 0.2711 0.4484
0.0223 0.2826 1
0.0218 0.3093 0.3138
0.0207 0.3301 0.4034
0.0202 0.3947 0.6358
0.0102 0.357 1
0.0205 0.2672 0.7719
0.0079 0.3645 0.3645
0.0122 0.3238 0.3701
0.0695 0.3249 0.3249
0.0425 0.3892 0.8115
0.0205 0.3299 0.4028
0.0212 0.3722 0.6522
0.0122 0.3143 0.8659
0.0229 0.321 0.4681
0.053 0.3269 0.3391
0.0122 0.2545 0.272
0.0202 0.3241 0.3961
0.0315 0.3847 1
0.0207 0.3299 0.4071
0.01 0.3628 0.4545
0.011 0.3932 0.5274
0.01 0.3185 0.3155
0.0321 0.3847 1
0.0309 0.3671 1
0.0091 0.3804 1
0.0113 0.3807 1
0.0109 0.3484 1
0.01 0.2953 0.2953
0.0079 0.3645 0.3645
0.0225 0.3313 0.7772
0.0196 0.27 0.7732
0.0216 0.3751 0.6975
0.0453 0.2785 0.2873
0.0206 0.2657 0.7706
0.0222 0.2834 0.703
0.0104 0.3645 0.4785
0.0231 0.2614 0.7719
0.0091 0.3804 1
0.0106 0.2946 0.3248
0.0122 0.3238 0.3701
0.0207 0.255 1
0.0243 0.2614 0.7719
0.0235 0.265 0.3753
0.0212 0.3032 0.3135
0.0204 0.2891 0.3503
0.0411 0.354 0.3531
0.0206 0.2657 0.7706
0.0198 0.3488 0.8337
0.0102 0.3496 0.3703
0.0099 0.3546 0.481
0.0104 0.3645 0.4785
0.0319 0.3867 0.5703
0.0113 0.3878 1
0.0535 0.2639 0.3727
0.0098 0.2948 0.2948
0.0197 0.27 0.7732
0.0403 0.2561 0.2698
0.0225 0.3316 0.7772
0.0079 0.3645 0.3645
0.0311 0.3812 0.6147
0.0122 0.2545 0.272
0.0098 0.3052 0.3489
0.0344 0.2692 0.3015
0.0219 0.2684 1
0.032 0.3649 1
0.0429 0.2803 0.297
0.0223 0.3749 0.4434
0.0218 0.3935 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LOAG_00684 (Loa Loa (eye worm)), hypothetical protein
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