Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | nuclear receptor subfamily 1, group H, member 4 | 476 aa | 402 aa | 28.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | UDP-galactopyranose mutase | 0.0125 | 0.0128 | 0.5 |
Mycobacterium leprae | Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). | 0.098 | 0.4661 | 1 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0385 | 0.1509 | 0.1398 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0385 | 0.1509 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0125 | 0.0128 | 1 |
Chlamydia trachomatis | dehyroquinate synthase | 0.0246 | 0.0769 | 0.0649 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0246 | 0.0769 | 0.0794 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0125 | 0.0128 | 0.5 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0631 | 0.281 | 0.2716 |
Echinococcus granulosus | cdgsh iron sulfur domain containing protein | 0.0236 | 0.072 | 1 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0246 | 0.0769 | 0.0794 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1646 | 0.8188 | 1 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0385 | 0.1509 | 0.1398 |
Toxoplasma gondii | chorismate synthase, putative | 0.1988 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0128 | 1 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0631 | 0.281 | 0.2716 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1771 | 0.8849 | 0.8834 |
Mycobacterium ulcerans | chorismate synthase | 0.1988 | 1 | 1 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0246 | 0.0769 | 0.9601 |
Onchocerca volvulus | 0.0125 | 0.0128 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0128 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0385 | 0.1509 | 0.5 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0631 | 0.281 | 0.2716 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0128 | 1 |
Plasmodium falciparum | chorismate synthase | 0.1988 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0128 | 1 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.098 | 0.4661 | 0.5624 |
Plasmodium vivax | chorismate synthase | 0.1988 | 1 | 1 |
Schistosoma mansoni | CDGSH-type Zn finger-containing protein-like protein | 0.0251 | 0.0795 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0125 | 0.0128 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0128 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0128 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1771 | 0.8849 | 0.8834 |
Schistosoma mansoni | hypothetical protein | 0.0251 | 0.0795 | 1 |
Brugia malayi | hypothetical protein | 0.0125 | 0.0128 | 1 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0631 | 0.281 | 0.5915 |
Mycobacterium leprae | 3-dehydroquinate synthase AroB | 0.0246 | 0.0769 | 0.1412 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0246 | 0.0769 | 0.0649 |
Echinococcus multilocularis | cdgsh iron sulfur domain containing protein | 0.0236 | 0.072 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0125 | 0.0128 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 38 nM | Agonist activity at FXR | ChEMBL. | 23040732 |
EC50 (binding) | = 0.038 uM | Effective concentration against farnesoid X receptor (FXR) | ChEMBL. | 15893927 |
EC50 (binding) | = 0.038 uM | Effective concentration against farnesoid X receptor (FXR) | ChEMBL. | 15893927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.