Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin D1 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B3 | Starlite/ChEMBL | References |
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.1735 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.1735 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0059 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0065 | 0.0182 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.1735 | 1 |
Schistosoma mansoni | cyclin B3 | 0.022 | 0.4934 | 0.8423 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.1735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.4226 | 0.4226 |
Echinococcus multilocularis | serotonin receptor | 0.025 | 0.5857 | 1 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0816 | 0.1394 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.1735 | 1 |
Echinococcus granulosus | cyclin b3 | 0.0086 | 0.0816 | 0.1394 |
Trichomonas vaginalis | cyclin A, putative | 0.0116 | 0.1735 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.1735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1735 | 0.1735 |
Echinococcus multilocularis | cyclin B3 1 | 0.0086 | 0.0816 | 0.1394 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.022 | 0.4934 | 0.4934 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0816 | 0.1394 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0816 | 0.1394 |
Echinococcus granulosus | cyclin B3 1 | 0.0086 | 0.0816 | 0.1394 |
Onchocerca volvulus | 0.0116 | 0.1735 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1735 | 0.1735 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.1735 | 1 |
Echinococcus granulosus | cyclin B | 0.0116 | 0.1735 | 0.2963 |
Echinococcus multilocularis | serotonin receptor | 0.025 | 0.5857 | 1 |
Echinococcus multilocularis | cyclin b3 | 0.0086 | 0.0816 | 0.1394 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0385 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0116 | 0.1735 | 0.1735 |
Entamoeba histolytica | cyclin, putative | 0.0116 | 0.1735 | 1 |
Schistosoma mansoni | cyclin B | 0.0116 | 0.1735 | 0.2963 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0385 | 1 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.022 | 0.4934 | 0.4934 |
Plasmodium falciparum | cyclin | 0.0086 | 0.0816 | 0.5 |
Echinococcus multilocularis | cyclin B | 0.0116 | 0.1735 | 0.2963 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0116 | 0.1735 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.1735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0816 | 0.1394 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.025 | 0.5857 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0385 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0116 | 0.1735 | 0.1735 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0816 | 0.1394 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0816 | 0.1394 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0816 | 0.1394 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.022 | 0.4934 | 0.8423 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.5857 | 0.5857 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.022 | 0.4934 | 0.8423 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.5857 | 0.5857 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0816 | 0.1394 |
Schistosoma mansoni | cyclins | 0.0086 | 0.0816 | 0.1394 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0816 | 0.1394 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0816 | 0.1394 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.025 | 0.5857 | 1 |
Echinococcus granulosus | cyclins | 0.0086 | 0.0816 | 0.1394 |
Echinococcus multilocularis | cyclins | 0.0086 | 0.0816 | 0.1394 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.02 uM | Inhibition of Cyclin-dependent kinase 2-cyclin E | ChEMBL. | 15537345 |
IC50 (binding) | = 0.02 uM | Inhibition of Cyclin-dependent kinase 2-cyclin E | ChEMBL. | 15537345 |
IC50 (binding) | > 0.27 uM | Inhibition of Cyclin-dependent kinase 1-cyclin B | ChEMBL. | 15537345 |
IC50 (binding) | > 0.27 uM | Inhibition of Cyclin-dependent kinase 1-cyclin B | ChEMBL. | 15537345 |
IC50 (functional) | = 0.49 uM | Inhibition of human colon carcinoma cell (HCT116) proliferation | ChEMBL. | 15537345 |
IC50 (functional) | = 0.49 uM | Inhibition of human colon carcinoma cell (HCT116) proliferation | ChEMBL. | 15537345 |
IC50 (binding) | = 2.9 uM | Inhibition of Cyclin-dependent kinase 4-cyclin D1 | ChEMBL. | 15537345 |
IC50 (binding) | = 2.9 uM | Inhibition of Cyclin-dependent kinase 4-cyclin D1 | ChEMBL. | 15537345 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15537345 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.