Detailed information for compound 332901

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.358 | Formula: C16H12F3N5O3S
  • H donors: 2 H acceptors: 5 LogP: 2.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(nn1C(=O)c1c(F)ccc(c1F)F)Nc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C16H12F3N5O3S/c1-8-21-16(22-9-2-4-10(5-3-9)28(20,26)27)23-24(8)15(25)13-11(17)6-7-12(18)14(13)19/h2-7H,1H3,(H,22,23)(H2,20,26,27)
  • InChiKey: FVCARQMVVSNDMM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin B3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi G protein-coupled receptor 0.0142 0.7414 0.6608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.7414 0.7365
Schistosoma mansoni myosin xvIII 0.0142 0.7414 0.7365
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0142 0.7414 0.7365
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Brugia malayi AKH receptor 0.0142 0.7414 0.6608
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) neuropeptide F receptor 0.0142 0.7414 0.6608
Schistosoma mansoni amine GPCR 0.0142 0.7414 0.7365
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus multilocularis fmrfamide receptor 0.0142 0.7414 0.7365
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Trypanosoma cruzi cyclin, putative 0.0073 0.2376 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0142 0.7414 0.7365
Brugia malayi ORL1-like opioid receptor 0.0142 0.7414 0.6608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.7414 0.7365
Plasmodium falciparum cyclin 0.0043 0.0185 0.5
Loa Loa (eye worm) cyclin domain-containing protein 0.0177 1 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0073 0.2376 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus multilocularis cyclin B 0.0073 0.2376 0.2232
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Schistosoma mansoni biogenic amine receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0142 0.7414 0.7365
Echinococcus granulosus orexin receptor type 2 0.0142 0.7414 0.7365
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0142 0.7414 0.7365
Schistosoma mansoni adenoreceptor 0.0142 0.7414 0.7365
Echinococcus granulosus fmrfamide receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0142 0.7414 0.6608
Brugia malayi neuropeptide F receptor 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Trichomonas vaginalis cyclin B, putative 0.0073 0.2376 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.7414 0.7365
Echinococcus multilocularis dro:myosuppressin receptor 0.0142 0.7414 0.7365
Echinococcus granulosus 7TM GPCR rhodopsin 0.0142 0.7414 0.7365
Brugia malayi follicle stimulating hormone receptor 0.0142 0.7414 0.6608
Echinococcus granulosus neuropeptide Y receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis G protein coupled receptor 139 0.0142 0.7414 0.7365
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0142 0.7414 0.6608
Brugia malayi Dopamine receptor 0.0142 0.7414 0.6608
Brugia malayi Dopamine receptor protein 1 0.0142 0.7414 0.6608
Schistosoma mansoni biogenic amine receptor 0.0142 0.7414 0.7365
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0142 0.7414 0.6608
Brugia malayi G-protein coupled receptor 0.0142 0.7414 0.6608
Trypanosoma cruzi cyclin, putative 0.0073 0.2376 0.5
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0073 0.2376 0.5
Brugia malayi Dopamine receptor protein 2 0.0142 0.7414 0.6608
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0142 0.7414 0.7365
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Trichomonas vaginalis cyclins, putative 0.0073 0.2376 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0185 0.078
Echinococcus granulosus neuropeptide receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.7414 0.7365
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Trichomonas vaginalis cyclin B3, putative 0.0043 0.0185 0.078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0142 0.7414 0.7365
Schistosoma mansoni neuropeptide F-like receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus granulosus g protein coupled receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) G-protein coupled receptor 0.0142 0.7414 0.6608
Echinococcus multilocularis neuropeptides capa receptor 0.0142 0.7414 0.7365
Brugia malayi Serotonin receptor 0.0142 0.7414 0.6608
Schistosoma mansoni amine GPCR 0.0142 0.7414 0.7365
Loa Loa (eye worm) G-protein coupled receptor 0.0142 0.7414 0.6608
Onchocerca volvulus Neuropeptide F receptor homolog 0.0142 0.7414 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0142 0.7414 0.6608
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0142 0.7414 0.7365
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0142 0.7414 0.7365
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Onchocerca volvulus 0.0142 0.7414 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus granulosus alpha 1A adrenergic receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) neuropeptide F receptor 0.0142 0.7414 0.6608
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Onchocerca volvulus 0.0142 0.7414 1
Echinococcus granulosus cyclin B 0.0073 0.2376 0.2232
Echinococcus multilocularis neuropeptides capa receptor 0.0142 0.7414 0.7365
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0142 0.7414 0.7365
Schistosoma mansoni opsin-like receptor 0.0142 0.7414 0.7365
Schistosoma mansoni neuropeptide F-like receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis allatostatin A receptor 0.0142 0.7414 0.7365
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Echinococcus granulosus neuropeptide receptor A26 0.0142 0.7414 0.7365
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Brugia malayi Serotonin receptor 0.0142 0.7414 0.6608
Brugia malayi G-protein coupled receptor 0.0142 0.7414 0.6608
Trichomonas vaginalis cyclin D, putative 0.0043 0.0185 0.078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Schistosoma mansoni amine GPCR 0.0142 0.7414 0.7365
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.7414 0.7365
Echinococcus granulosus allatostatin A receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis g protein coupled receptor 0.0142 0.7414 0.7365
Echinococcus granulosus neuropeptide FF receptor 2 0.0142 0.7414 0.7365
Echinococcus multilocularis sex peptide receptor 0.0142 0.7414 0.7365
Schistosoma mansoni histamine h1 receptor 0.0142 0.7414 0.7365
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0142 0.7414 0.7365
Echinococcus granulosus 7tm_1 domain containing protein 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus multilocularis fmrfamide receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0177 1 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Trichomonas vaginalis cyclins, putative 0.0073 0.2376 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0142 0.7414 0.6608
Echinococcus multilocularis serotonin receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis neuropeptide Y receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0142 0.7414 1
Onchocerca volvulus 0.0142 0.7414 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.0073 0.2376 0.5
Onchocerca volvulus 0.0142 0.7414 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0142 0.7414 0.7365
Schistosoma mansoni hypothetical protein 0.0142 0.7414 0.7365
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus granulosus tm gpcr rhodopsin 0.0142 0.7414 0.7365
Trichomonas vaginalis cyclin B, putative 0.0043 0.0185 0.078
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0142 0.7414 0.6608
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis somatostatin receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis serotonin receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0142 0.7414 0.7365
Onchocerca volvulus 0.0142 0.7414 1
Onchocerca volvulus 0.0142 0.7414 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Schistosoma mansoni opsin-like receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis neuropeptide receptor 0.0142 0.7414 0.7365
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis neuropeptide FF receptor 2 0.0142 0.7414 0.7365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0142 0.7414 0.7365
Echinococcus multilocularis neuropeptide s receptor 0.0142 0.7414 0.7365
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0142 0.7414 0.7365
Schistosoma mansoni biogenic amine (5HT) receptor 0.0142 0.7414 0.7365
Brugia malayi G protein-coupled receptor F59B2.13 0.0142 0.7414 0.6608
Echinococcus multilocularis neuropeptide receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0177 1 1
Schistosoma mansoni amine GPCR 0.0142 0.7414 0.7365
Echinococcus granulosus g protein coupled receptor 0.0142 0.7414 0.7365
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Onchocerca volvulus 0.0142 0.7414 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Trichomonas vaginalis cyclin A, putative 0.0073 0.2376 1
Onchocerca volvulus 0.0142 0.7414 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0142 0.7414 0.7365
Echinococcus granulosus neuropeptide Y receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0142 0.7414 0.6608
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0142 0.7414 0.6608
Onchocerca volvulus 0.0142 0.7414 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0142 0.7414 0.6608
Schistosoma mansoni biogenic amine (5HT) receptor 0.0142 0.7414 0.7365
Echinococcus granulosus sex peptide receptor 0.0142 0.7414 0.7365
Trichomonas vaginalis cyclin B, putative 0.0073 0.2376 1
Schistosoma mansoni hypothetical protein 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Onchocerca volvulus 0.0142 0.7414 1
Echinococcus granulosus neuropeptide receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0142 0.7414 0.7365
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0142 0.7414 0.7365
Onchocerca volvulus 0.0142 0.7414 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Brugia malayi putative neuropeptide receptor NPR1 0.0142 0.7414 0.6608
Brugia malayi putative neuropeptide receptor 0.0142 0.7414 0.6608
Trypanosoma brucei mitotic cyclin 6 0.0073 0.2376 0.5
Schistosoma mansoni opsin-like receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis neuropeptide receptor A26 0.0142 0.7414 0.7365
Brugia malayi Melatonin receptor type 1A 0.0142 0.7414 0.6608
Echinococcus granulosus tm gpcr rhodopsin 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) melatonin receptor type 1A 0.0142 0.7414 0.6608
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0142 0.7414 0.7365
Echinococcus granulosus G protein coupled receptor 139 0.0142 0.7414 0.7365
Echinococcus granulosus tm gpcr rhodopsin 0.0142 0.7414 0.7365
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0142 0.7414 0.6608
Onchocerca volvulus 0.0142 0.7414 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Trichomonas vaginalis cyclin B, putative 0.0073 0.2376 1
Brugia malayi sulfakinin receptor protein 0.0142 0.7414 0.6608
Schistosoma mansoni neuropeptide receptor 0.0142 0.7414 0.7365
Entamoeba histolytica cyclin, putative 0.0073 0.2376 1
Onchocerca volvulus 0.0142 0.7414 1
Echinococcus multilocularis orexin receptor type 2 0.0142 0.7414 0.7365
Schistosoma mansoni neuropeptide f receptor 76f 0.0142 0.7414 0.7365
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Trichomonas vaginalis cyclins, putative 0.0073 0.2376 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus multilocularis g protein coupled receptor 0.0142 0.7414 0.7365
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0142 0.7414 0.7365
Brugia malayi neuropeptide F receptor 0.0142 0.7414 0.6608
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Leishmania major cyclin 0.0073 0.2376 0.5
Schistosoma mansoni cyclin B 0.0073 0.2376 0.2232
Brugia malayi GnHR receptor homolog 0.0142 0.7414 0.6608
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus granulosus peptide allatostatin:somatostatin 0.0142 0.7414 0.7365
Schistosoma mansoni cyclin B3 0.0177 1 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus granulosus somatostatin receptor 0.0142 0.7414 0.7365
Trichomonas vaginalis cyclin D, putative 0.0043 0.0185 0.078
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Echinococcus granulosus biogenic amine 5HT receptor 0.0142 0.7414 0.7365
Schistosoma mansoni hypothetical protein 0.0142 0.7414 0.7365
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0142 0.7414 0.7365
Onchocerca volvulus 0.0142 0.7414 1
Echinococcus multilocularis neuropeptide Y receptor 0.0142 0.7414 0.7365
Trichomonas vaginalis cyclins, putative 0.0073 0.2376 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.7414 0.7365
Brugia malayi RE15519p 0.0142 0.7414 0.6608
Echinococcus granulosus serotonin receptor 0.0142 0.7414 0.7365
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Echinococcus granulosus g-protein coupled receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0142 0.7414 0.7365
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Schistosoma mansoni alpha-1 adrenergic receptor 0.0142 0.7414 0.7365
Echinococcus granulosus dro:myosuppressin receptor 0.0142 0.7414 0.7365
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0142 0.7414 0.7365
Echinococcus granulosus hypothetical protein 0.0142 0.7414 0.7365
Echinococcus multilocularis g-protein coupled receptor 0.0142 0.7414 0.7365
Schistosoma mansoni hypothetical protein 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Schistosoma mansoni growth hormone secretagogue receptor 0.0142 0.7414 0.7365
Trichomonas vaginalis cyclin B, putative 0.0073 0.2376 1
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Schistosoma mansoni neuropeptide receptor 0.0142 0.7414 0.7365
Schistosoma mansoni neuropeptide receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0142 0.7414 0.7365
Brugia malayi larval opioid receptor 0.0142 0.7414 0.6608
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Schistosoma mansoni biogenic amine receptor 0.0142 0.7414 0.7365
Echinococcus granulosus neuropeptide s receptor 0.0142 0.7414 0.7365
Onchocerca volvulus 0.0142 0.7414 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Onchocerca volvulus 0.0142 0.7414 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0142 0.7414 0.7365
Echinococcus granulosus neuropeptides capa receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.7414 0.7365
Echinococcus granulosus g protein coupled receptor 0.0142 0.7414 0.7365
Onchocerca volvulus 0.0142 0.7414 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0142 0.7414 0.7365
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Echinococcus granulosus neuropeptides capa receptor 0.0142 0.7414 0.7365
Echinococcus multilocularis g protein coupled receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Loa Loa (eye worm) TYRA-2 protein 0.0142 0.7414 0.6608
Schistosoma mansoni amine GPCR 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608
Brugia malayi hypothetical protein 0.0142 0.7414 0.6608
Trypanosoma cruzi cyclin 6, putative 0.0073 0.2376 0.5
Trichomonas vaginalis cyclins, putative 0.0043 0.0185 0.078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.7414 0.7365
Schistosoma mansoni neuropeptide receptor 0.0142 0.7414 0.7365
Loa Loa (eye worm) hypothetical protein 0.0142 0.7414 0.6608

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0032 uM Inhibition of Cyclin B-cyclin-dependent kinase 1 ChEMBL. 15974571
IC50 (binding) = 0.0032 uM Inhibition of Cyclin B-cyclin-dependent kinase 1 ChEMBL. 15974571
IC50 (functional) = 0.22 uM In vitro inhibitory concentrationagainst cell proliferation in human HeLa (cervical adenocarcinoma) tumor cells ChEMBL. 15974571
IC50 (functional) = 0.22 uM In vitro inhibitory concentrationagainst cell proliferation in human HeLa (cervical adenocarcinoma) tumor cells ChEMBL. 15974571
IC50 (functional) = 1.6 uM In vitro inhibitory concentration against cell proliferation in human SK-OV-3 (ovarian adenocarcinoma)tumor cells ChEMBL. 15974571
IC50 (functional) = 1.6 uM In vitro inhibitory concentration against cell proliferation in human SK-OV-3 (ovarian adenocarcinoma)tumor cells ChEMBL. 15974571

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15974571

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.